Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Pregnancy cat. B2(AU)
Legal status OTC(UK)
Routes Oral, topical
Pharmacokinetic data
Protein binding <20%
Half-life 13 hours
Excretion Renal
CAS number 642-72-8 YesY
ATC code A01AD02 G02CC03 M01AX07 M02AA05
PubChem CID 12555
ChemSpider 12036 YesY
UNII 4O21U048EF YesY
KEGG D07516 YesY
Chemical data
Formula C19H23N3O 
Mol. mass 309.405 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.[1]


Medical use

It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.


There are no contraindications to the use of Benzydamine except for known hypersensitivity.

Side effects

Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur.


It selectively binds to inflamed tissues (Prostaglandin synthetase inhibitor) and is normally free of adverse systemic effects. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.[2]

Recreational use

Benzydamine has been misused recreationally. In overdosages it acts a deliriant and CNS stimulant.[2] Such misuse, particularly among teenagers, has been reported in Poland,[2] Brazil[3][4] and Romania.

See also


  1. ^ Turnbull, R. S. (1995). "Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions". Journal (Canadian Dental Association) 61 (2): 127–134. PMID 7600413.  edit
  2. ^ a b c Anand, J. S.; Lukasik–Glębocka, M.; Korolkiewicz, R. P. (2007). "Letter to the Editor: Recreational abuse with benzydamine hydrochloride (tantum rosa)". Clinical Toxicology 45 (2): 198–199. doi:10.1080/15563650600981210. PMID 17364645.  edit
  3. ^ Opaleye, E. S.; Noto, A. R.; Sanchez, Z. M.; Moura, Y. G.; Galduróz, J. C.; Carlini, E. A. (2009). "Recreational use of benzydamine as a hallucinogen among street youth in Brazil". Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 31 (3): 208–213. doi:10.1590/S1516-44462009000300005. PMID 19784487.  edit
  4. ^ Mota, D. M.; Costa, A. A.; Teixeira, C. D. S.; Bastos, A. A.; Dias, M. F. (2010). "Use abusive of benzydamine in Brazil: An overview in pharmacovigilance" (in portuguese). Ciencia & saude coletiva 15 (3): 717–724. doi:10.1590/S1413-81232010000300014. PMID 20464184.  edit

External links