2C-T-8

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IUPACName = 2- [4- [(Cyclopropylmethyl)thio] -2,5-dimethoxyphenyl] ethanamine
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CASNo = 207740-27-0
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SMILES = COc2cc(SCC1CC1)c(cc2CCN)OC
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Formula = C₁₄H₂₁NO₂S
MolarMass = 267.39 g/mol
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2C-T-8 is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin, sometimes used as an entheogen.

Chemistry

The full name of the chemical is 2,5-dimethoxy-4-cyclopropylmethylthiophenethylamine. The compound is reported to have a bad taste and smell.

Effects

In his book "PiHKAL (Phenethylamines i Have Known And Loved)", Shulgin lists the dosage range as 30 to 50 mg. 2C-T-8 is generally taken orally, and effects typically last 10 to 15 hours. Experiences have varied between insight and creativity at low doses to hypersensitivity and paranoia at higher doses. A "thinking-connection" that is characteristic of the 2C-T group is evident in this chemical in stark contrast to the "pure euphoria" of phenethylamines such as MDMA. [CitePiHKAL]

Legality

2C-T-8 is unscheduled and uncontrolled in the United States, but possession and sales of 2C-T-8 will probably be prosecuted under the Federal Analog Act because of its structural similarities to 2C-T-7. However, 2C-T-8, unlike many other phenethylamines has not been sold by internet retailers. In the wake of Operation Web Tryp in July 2004, the issue of possession and sales of 2C-T-8 and other similar chemicals will probably be resolved in the courtroom as will the fate of this rare but unique psychedelic. There have been no reported deaths from 2C-T-8.

Pharmacology

The mechanism that produces 2C-T-8’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT_2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.

Dangers

The toxicity of 2C-T-8 is not well documented. 2C-T-8 is somewhat less potent than 2C-T-7, but it may be expected that at higher doses it would display similar toxicity to that of other phenethylamines of the 2C-T family. Other phenethylamine derivatives substituted with an alkylthio group at the 4 position such as 2C-T-7 and 4-MTA are known to act as selective monoamine oxidase A inhibitors, a side effect which can lead to lethal serotonin syndrome when they are combined with stimulant drugs.

There have been no confirmed deaths due to 2C-T-8Fact|date=March 2008, though this may in part be due to its rarity and limited usage. Of the 2C-T family, there have been a few confirmed deaths due to 2C-T-7, which involved either insufflating large (>30 mg) doses [ [http://www.erowid.org/chemicals/2ct7/2ct7_death1.shtml Erowid.org] ] [ [http://www.erowid.org/chemicals/2ct7/2ct7_death2.shtml Erowid.org] ] and in one case an unknown oral dose was combined with 200 mg MDMA. [ [http://www.erowid.org/chemicals/2ct7/2ct7_death3.shtml Erowid.org] ]

Popularity

2C-T-8 is unknown on the black market. Limited accounts of 2C-T-8 can be found in the book PiHKAL.

References

External links

* [http://www.erowid.org/library/books_online/pihkal/pihkal044.shtml 2C-T-8 Entry in PiHKAL]