Meclofenoxate

Meclofenoxate

Systematic (IUPAC) name
2-Dimethylaminoethyl (4-chlorophenoxy)acetate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	51-68-3
ATC code	N06BX01
PubChem	CID 4039
UNII	C76QQ2I0RG Y
KEGG	D00993 Y
Chemical data
Formula	C12H16ClNO3
Mol. mass	257.713
SMILES	eMolecules & PubChem
Y(what is this?)  (verify)

Meclofenoxate (Lucidril), also known as centrophenoxine, is a drug used to treat the symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). DMAE is a natural substance, found especially in fish. pCPA is a synthetic compound that resembles a variety of plant hormones called auxins.

In elderly patients, it has been clinically shown to improve memory, have a mentally stimulating effect, and improve general cognition.^[1] Meclofenoxate also increases cellular membrane phospholipids.^{[citation needed]}

It is also used off-label as a nootropic, often combined with a racetam drug such as piracetam. A typical nootropic dose is 250–3000 mg taken in 1 or more doses.^{[citation needed]}

Side effects and contraindications

Meclofenoxate is generally considered safe. However possible side effects may include nausea or mild dizziness. People with severely high blood pressure or convulsive disorders such as epilepsy should avoid meclofenoxate.^{[2][unreliable source?]} Large doses may cause tight jaw clenching.

See also

• Cyprodenate

References

1. ^ Marcer, D; Hopkins, SM (1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and ageing 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662. 
2. ^ Centrophenoxine Page @ The American Academy of Anti-Aging Medicine