Procyclidine

Procyclidine
Procyclidine
Systematic (IUPAC) name
1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a605037
Pregnancy cat.  ?
Legal status  ?
Routes oral, im, iv
Pharmacokinetic data
Protein binding ~100%-albumin
Half-life ~12 h
Identifiers
CAS number 77-37-2
77-37-2 (free base)
ATC code N04AA04
PubChem CID 207841
DrugBank APRD00383
ChemSpider 4750
UNII C6QE1Q1TKR YesY
ChEMBL CHEMBL1761 YesY
Chemical data
Formula C19H30ClNO 
Mol. mass 323.9 g/mol
 YesY(what is this?)  (verify)
Not to be confused with Phencyclidine.

Procyclidine is an anticholinergic drug principally used for the treatment of:

Contents

Uses

It is used in patients with parkinsonism and akathisia and to reduce the side effects of antipsychotic treatment given for schizophrenia. Procyclidine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia.

Procyclidine is also sometimes used for the treatment of dystonia (but not tardive dyskinesia), a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.

Overdose

Signs of procyclidine overdose are those of an anticholinergic and include confusion, agitation and sleeplessness that can last up to or more than 24 hours. Pupils become dilated and unreactive to light. Tachycardia (fast heart beat), as well as auditory and visual hallucinations have also been reported.

Other known symptoms of overdose are: clumsiness or unsteadiness, being severely drowsy, having a severely dry mouth, nose, or throat, having an altered mood or other mental changes, seizures, being short of breath or having troubled breathing, a dry and warm, flushed skin.

A suspected overdose with severe life-threatening symptoms should immediately be brought to medical attention, where reversal can be attempted with physostigmine administered intravenously or subcutaneously.

Chemistry

Procyclidine, 1-cyclohexyl-1-phenyl-3-pyrrolidinopropan-1-ol, is synthesized in the exact same manner as was seen for trihexyphenidyl, except this time the linear synthesis begins with the preparation of 3-(1-pyrrolidino)propiophenone.

  • E. Jassmann, H. Pfanz, DE 1084734  (1960).
  • E.M. Boffort, U.S. Patent 2,826,590 (1958).
  • D.W. Adamson, P.A. Barrett, S. Wilkinson, J. Chem. Soc., 52(1951).

References

v · d · eAntiparkinson agents (N04)
Dopaminergics
Etilevodopa • Droxidopa • Levodopa# • Melevodopa
DA receptor agonists
Ladostigil • Lazabemide • Mofegiline • Pargyline • Rasagiline • Selegiline
Anticholinergics
Others

M: CNS

anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug(N1A/2AB/C/3/4/7A/B/C/D)

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Look at other dictionaries:

  • Procyclidine hydrochloride — drugbox IUPAC name = 1 cyclohexyl 1 phenyl 3 pyrrolidin 1 yl propan 1 ol hydrochloride width= CAS number = 77 37 2 ATC prefix = N04 ATC suffix = AA04 PubChem = 207841 DrugBank = APRD00383 C=19 | H=30 | Cl=1 | N=1 | O=1 molecular weight = 323.9… …   Wikipedia

  • procyclidine — noun An anticholinergic drug mainly used to treat drug induced parkinsonism, akathisia and acute dystonia …   Wiktionary

  • procyclidine — n. an anticholinergic drug used to reduce muscle tremor and rigidity in parkinsonism. It is administered by mouth; common side effects include dry mouth, blurred vision, and giddiness. Trade names: Arpicolin, Kemadrin …   Medical dictionary

  • procyclidine — n. an antimuscarinic drug used to reduce muscle tremor and rigidity in parkinsonism. It is administered by mouth or injection; common side effects include dry mouth, blurred vision, and giddiness. Trade names: Arpicolin, Kemadrin …   The new mediacal dictionary

  • procyclidine — noun drug (trade name Kemadrin) used to reduce tremors in Parkinsonism • Syn: ↑Kemadrin • Usage Domain: ↑trade name (for: ↑Kemadrin) • Hypernyms: ↑muscle relaxant …   Useful english dictionary

  • procyclidine hydrochloride — An anticholinergic agent used in the treatment of paralysis agitans and drug induced parkinsonism. * * * pro·cy·cli·dine hy·dro·chlo·ride (pro siґklĭ dēn) [USP] a synthetic anticholinergic with a direct antispasmodic effect on smooth… …   Medical dictionary

  • procyclidine methochloride — An anticholinergic drug used in the treatment of functional gastrointestinal spasm. SYN: tricyclamol chloride …   Medical dictionary

  • Проциклидин (Procyclidine) — лекарственное вещество, сходное по своему действию с атропином; применяется для уменьшения тремора и ригидности мышц при паркинсонизме. Может назначаться внутрь или в инъекциях; возможные побочные эффекты: сухость во рту, нарушение зрения и… …   Медицинские термины

  • ПРОЦИКЛИДИН — (procyclidine) лекарственное вещество, сходное по своему действию с атропином; применяется для уменьшения тремора и ригидности мышц при паркинсонизме. Может назначаться внутрь или в инъекциях; возможные побочные эффекты: сухость во рту, нарушение …   Толковый словарь по медицине

  • Muscarinic antagonist — In neurochemistry, a muscarinic receptor antagonist is an agent that reduces the activity of the muscarinic acetylcholine receptor. Acetylcholine (often abbreviated ACh) is a neurotransmitter, whose receptor is a protein found in synapses and… …   Wikipedia

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