- Dichlorvos
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Dichlorvos Systematic (IUPAC) name 2,2-dichlorovinyl dimethyl phosphate Clinical data AHFS/Drugs.com International Drug Names Pregnancy cat. ? Legal status ? Identifiers CAS number 62-73-7 ATCvet code QP52AB03 QP53AF04 PubChem CID 3039 ChemSpider 2931 UNII 7U370BPS14 KEGG D03791 ChEBI CHEBI:34690 ChEMBL CHEMBL167911 Chemical data Formula C4H7Cl2O4P Mol. mass 220.98 g/mol SMILES eMolecules & PubChem (what is this?) (verify) Dichlorvos or 2,2-dichlorovinyl dimethyl phosphate (DDVP) is a highly volatile organophosphate, widely used as a insecticide to control household pests, in public health, and protecting stored product from insects. It is effective against mushroom flies, aphids, spider mites, caterpillars, thrips, and whiteflies in greenhouse, outdoor fruit, and vegetable crops. It is also used in the milling and grain handling industries and to treat a variety of parasitic worm infections in dogs, livestock, and humans. It is fed to livestock to control bot fly larvae in the manure. It acts against insects as both a contact and a stomach poison. It is available as an aerosol and soluble concentrate. It is also used in pet collars and "no-pest strips" as pesticide-impregnated plastic. In this form it has recently been labeled for use against bed bugs
The United States Environmental Protection Agency first considered a ban on DDVP in 1981. Since then it has been close to being banned on several occasions, but continues to be available. Major concerns are over acute and chronic toxicity. There is no conclusive evidence of carcinogenicity to date, however a 2010 study found that each 10-fold increase in urinary concentration of organophosphate metabolites was associated with a 55% to 72% increase in the odds of ADHD in children.[1]
DDVP is absorbed through all routes of exposure. since it is an acetylcholinesterase inhibitor, its overdose symptoms are weakness, headache, tightness in chest, blurred vision, salivation, sweating, nausea, vomiting, diarrhea, and abdominal cramps.
Dichlorvos damages DNA of insects in museum collections.[2]
References
- ^ http://www.medscape.com/viewarticle/721892
- ^ Espeland M., Irestedt M., Johanson K. A., Åkerlund M., Bergh J.-E. & Källersjö M. (2010). "Dichlorvos exposure impedes extraction and amplification of DNA from insects in museum collections". Frontiers in Zoology 2010, 7: 2. doi:10.1186/1742-9994-7-2
- Extension Toxicology Network fact sheet
- Media Release from Australian Pesticides & Veterinary Medicines Authority
- Raeburn, Paul (Aug 2006). "Slow-Acting: After 25 years the EPA still won't ban a risky pesticide". Scientific American 295 (2): 26. PMID 16866280. http://www.sciam.com/article.cfm?chanID=sa004&articleID=000EDC34-3CC0-14C0-AFE483414B7F4945.
External links
- Material Safety Data Sheet (MSDS) for Dichlorvos
- BBC News: Insecticide ban amid cancer fears
- Australian Pesticides & Veterinary Medicines Authority Chemical Review Program - Dichlorvos
Antiparasitics – Anthelmintics (P02) Antiplatyhelmintic agents Antitrematodals
(schistosomicides)Binds tubulinOther/unknownquinoline (Praziquantel#, Oxamniquine#) • phenol (Bithionol) • thiazole (Niridazole) • arylsulfonate (Stibophen)Anticestodals
(taeniacides)Binds tubulinOther/unknownsalicylanilide (Niclosamide)# • aminoacridine (Quinacrine) • butyrophenone (Desaspidin) • chlorophenol (Dichlorophen)Antinematodal agents
(including
macrofilaricides)Binds tubulinbenzimidazole (Mebendazole#, Albendazole#, Thiabendazole, Fenbendazole, Ciclobendazole, Flubendazole)Other/unknownpiperazine (Piperazine • Diethylcarbamazine#) • thiazole (Levamisole#) • quinolinium (Pyrvinium) • benzylammonium (Bephenium) • naphthalenesulfonate (Suramin#) • TribendimidineM: IFT
helm,arth (acar)
helm, arth (lice), zoon
helm, arth
Ectoparasiticides / arthropod (P03A) Insecticide/pediculicide Chlorine-containing productsAcaricide/miticide/scabicide PyrethrinesSulfur-containing productsChlorine-containing productsOther/ungroupedM: IFT
helm,arth (acar)
helm, arth (lice), zoon
helm, arth
Cholinergics Receptor ligands Agonists: 77-LH-28-1 • AC-42 • AC-260,584 • Aceclidine • Acetylcholine • AF30 • AF150(S) • AF267B • AFDX-384 • Alvameline • AQRA-741 • Arecoline • Bethanechol • Butyrylcholine • Carbachol • CDD-0034 • CDD-0078 • CDD-0097 • CDD-0098 • CDD-0102 • Cevimeline • cis-Dioxolane • Ethoxysebacylcholine • LY-593,039 • L-689,660 • LY-2,033,298 • McNA343 • Methacholine • Milameline • Muscarine • NGX-267 • Ocvimeline • Oxotremorine • PD-151,832 • Pilocarpine • RS86 • Sabcomeline • SDZ 210-086 • Sebacylcholine • Suberylcholine • Talsaclidine • Tazomeline • Thiopilocarpine • Vedaclidine • VU-0029767 • VU-0090157 • VU-0152099 • VU-0152100 • VU-0238429 • WAY-132,983 • Xanomeline • YM-796
Antagonists: 3-Quinuclidinyl Benzilate • 4-DAMP • Aclidinium Bromide • Anisodamine • Anisodine • Atropine • Atropine Methonitrate • Benactyzine • Benzatropine (Benztropine) • Benzydamine • BIBN 99 • Biperiden • Bornaprine • CAR-226,086 • CAR-301,060 • CAR-302,196 • CAR-302,282 • CAR-302,368 • CAR-302,537 • CAR-302,668 • CS-27349 • Cyclobenzaprine • Cyclopentolate • Darifenacin • DAU-5884 • Dimethindene • Dexetimide • DIBD • Dicyclomine (Dicycloverine) • Ditran • EA-3167 • EA-3443 • EA-3580 • EA-3834 • Elemicin • Etanautine • Etybenzatropine (Ethylbenztropine) • Flavoxate • Himbacine • HL-031,120 • Ipratropium bromide • J-104,129 • Hyoscyamine • Mamba Toxin 3 • Mamba Toxin 7 • Mazaticol • Mebeverine • Methoctramine • Metixene • Myristicin • N-Ethyl-3-Piperidyl Benzilate • N-Methyl-3-Piperidyl Benzilate • Orphenadrine • Otenzepad • Oxybutynin • PBID • PD-102,807 • PD-0298029 • Phenglutarimide • Phenyltoloxamine • Pirenzepine • Piroheptine • Procyclidine • Profenamine • RU-47,213 • SCH-57,790 • SCH-72,788 • SCH-217,443 • Scopolamine (Hyoscine) • Solifenacin • Telenzepine • Tiotropium bromide • Tolterodine • Trihexyphenidyl • Tripitamine • Tropatepine • Tropicamide • WIN-2299 • Xanomeline • Zamifenacin; Others: 1st Generation Antihistamines (Brompheniramine, chlorphenamine, cyproheptadine, dimenhydrinate, diphenhydramine, doxylamine, mepyramine/pyrilamine, phenindamine, pheniramine, tripelennamine, triprolidine, etc) • Tricyclic Antidepressants (Amitriptyline, doxepin, trimipramine, etc) • Tetracyclic Antidepressants (Amoxapine, maprotiline, etc) • Typical Antipsychotics (Chlorpromazine, thioridazine, etc) • Atypical Antipsychotics (Clozapine, olanzapine, quetiapine, etc)Agonists: 5-HIAA • A-84,543 • A-366,833 • A-582,941 • A-867,744 • ABT-202 • ABT-418 • ABT-560 • ABT-894 • Acetylcholine • Altinicline • Anabasine • Anatoxin-a • AR-R17779 • Butyrylcholine • Carbachol • Cotinine • Cytisine • Decamethonium • Desformylflustrabromine • Dianicline • Dimethylphenylpiperazinium • Epibatidine • Epiboxidine • Ethanol • Ethoxysebacylcholine • EVP-4473 • EVP-6124 • Galantamine • GTS-21 • Ispronicline • Lobeline • MEM-63,908 (RG-3487) • Nicotine • NS-1738 • PHA-543,613 • PHA-709,829 • PNU-120,596 • PNU-282,987 • Pozanicline • Rivanicline • Sazetidine A • Sebacylcholine • SIB-1508Y • SIB-1553A • SSR-180,711 • Suberylcholine • TC-1698 • TC-1734 • TC-1827 • TC-2216 • TC-5214 • TC-5619 • TC-6683 • Tebanicline • Tropisetron • UB-165 • Varenicline • WAY-317,538 • XY-4083
Antagonists: 18-Methoxycoronaridine • α-Bungarotoxin • α-Conotoxin • Alcuronium • Amantadine • Anatruxonium • Atracurium • Bupropion (Amfebutamone) • Chandonium • Chlorisondamine • Cisatracurium • Coclaurine • Coronaridine • Dacuronium • Decamethonium • Dextromethorphan • Dextropropoxyphene • Dextrorphan • Diadonium • DHβE • Dimethyltubocurarine (Metocurine) • Dipyrandium • Dizocilpine (MK-801) • Doxacurium • Duador • Esketamine • Fazadinium • Gallamine • Hexafluronium • Hexamethonium (Benzohexonium) • Ibogaine • Isoflurane • Ketamine • Kynurenic acid • Laudexium (Laudolissin) • Levacetylmethadol • Malouetine • Mecamylamine • Memantine • Methadone • Methorphan (Racemethorphan) • Methyllycaconitine • Metocurine • Mivacurium • Morphanol (Racemorphanol) • Neramexane • Nitrous Oxide • Pancuronium • Pempidine • Pentamine • Pentolinium • Phencyclidine • Pipecuronium • Radafaxine • Rapacuronium • Rocuronium • Surugatoxin • Suxamethonium (Succinylcholine) • Thiocolchicoside • Toxiferine • Trimethaphan • Tropeinium • Tubocurarine • Vecuronium • XenonReuptake inhibitors PlasmalemmalCHT InhibitorsHemicholinium-3 (Hemicholine; HC3) • TriethylcholineVAChT InhibitorsEnzyme inhibitors ChAT inhibitors1-(-Benzoylethyl)pyridinium • 2-(α-Naphthoyl)ethyltrimethylammonium • 3-Chloro-4-stillbazole • 4-(1-Naphthylvinyl)pyridine • Acetylseco hemicholinium-3 • Acryloylcholine • AF64A • B115 • BETA • CM-54,903 • CatabolismAChE inhibitorsReversible: Carbamates: Aldicarb • Bendiocarb • Bufencarb • Carbaryl • Carbendazim • Carbetamide • Carbofuran • Chlorbufam • Chloropropham • Ethienocarb • Ethiofencarb • Fenobucarb • Fenoxycarb • Formetanate • Furadan • Ladostigil • Methiocarb • Methomyl • Miotine • Oxamyl • Phenmedipham • Pinmicarb • Pirimicarb • Propamocarb • Propham • Propoxur; Stigmines: Ganstigmine • Neostigmine • Phenserine • Physostigmine • Pyridostigmine • Rivastigmine; Others: Acotiamide • Ambenonium • Donepezil • Edrophonium • Galantamine • Huperzine A • Minaprine • Tacrine • Zanapezil
Irreversible: Organophosphates: Acephate • Azinphos-methyl • Bensulide • Cadusafos • Chlorethoxyfos • Chlorfenvinphos • Chlorpyrifos • Chlorpyrifos-Methyl • Coumaphos • Cyclosarin (GF) • Demeton • Demeton-S-Methyl • Diazinon • Dichlorvos • Dicrotophos • Diisopropyl fluorophosphate (Guthion) • Diisopropylphosphate • Dimethoate • Dioxathion • Disulfoton • EA-3148 • Echothiophate • Ethion • Ethoprop • Fenamiphos • Fenitrothion • Fenthion • Fosthiazate • GV • Isofluorophate • Isoxathion • Malaoxon • Malathion • Methamidophos • Methidathion • Metrifonate • Mevinphos • Monocrotophos • Naled • Novichok agent • Omethoate • Oxydemeton-Methyl • Paraoxon • Parathion • Parathion-Methyl • Phorate • Phosalone • Phosmet • Phostebupirim • Phoxim • Pirimiphos-Methyl • Sarin (GB) • Soman (GD) • Tabun (GA) • Temefos • Terbufos • Tetrachlorvinphos • Tribufos • Trichlorfon • VE • VG • VM • VR • VX; Others: Demecarium • Onchidal (Onchidella binneyi)BChE inhibitorsCymserine * Many of the acetylcholinesterase inhibitors listed above act as butyrylcholinesterase inhibitors.Others Choline (Lecithin) • Citicoline • Cyprodenate • Dimethylethanolamine (DMAE, deanol) • Glycerophosphocholine • Meclofenoxate (Centrophenoxine) • Phosphatidylcholine • Phosphatidylethanolamine • Phosphorylcholine • PirisudanolOthersAcetylcholine releasing agents: α-Latrotoxin • β-Bungarotoxin; Acetylcholine release inhibitors: Botulinum toxin (Botox); Acetylcholinesterase reactivators: Asoxime • Obidoxime • PralidoximeCategories:- Organochlorides
- Organophosphates
- Pesticides
- IARC Group 2B carcinogens
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Look at other dictionaries:
Dichlorvos — Général … Wikipédia en Français
Dichlorvos — Strukturformel Allgemeines Freiname Dichlorvos … Deutsch Wikipedia
dichlorvos — noun Etymology: dichlor + vinyl + phosphate Date: 1957 an organophosphorus insecticide and anthelmintic C4H7Cl2O4P used especially in veterinary medicine called also DDVP … New Collegiate Dictionary
dichlorvos — di·chlor·vos (dī klôrʹvōs , vəs, klōrʹ ) n. A nonpersistent organophosphorous pesticide, C4H7O4Cl2P, of low toxicity to humans. [di 1 + chloro + vinyl + phosphate.] * * * … Universalium
dichlorvos — noun A highly volatile organophosphate, 2,2 dichlorovinyl dimethyl phosphate (DDVP), widely used as a fumigant to control household pests and to protect stored product from insects … Wiktionary
dichlorvos — An anthelmintic in veterinary and human medicine. SYN: dichlorovos. * * * di·chlor·vos ( )dī klō(ə)r .väs, klȯ(ə)r , vəs n an organophosphorus insecticide and anthelmintic C4H7Cl2O4P used esp. in veterinary medicine called also DDVP * * *… … Medical dictionary
Dichlorvos — Di|chlor|vọs: Common Name für (2,2 Dichlorvinyl)dimethylphosphat (Abk.: DDVP), ein als Kontakt u. Fraßgift wirkendes Insektizid … Universal-Lexikon
dichlorvos — di·chlor·vos … English syllables
dichlorvos — (ˈ)dī¦klō(ə)rˌväs, lȯ( , vəs noun ( es) Etymology: dichlor + vinyl + phosphate : an organophosphorus insecticide and anthelmintic C4H7Cl2O4P used especially in veterinary medicine; 2,2 dichlorovinyl dimethyl phosphate called also DDVP … Useful english dictionary
62-73-7 — Dichlorvos Dichlorvos Général … Wikipédia en Français