IUPAC_name = 5- [3- [(1"R",2"R")-1- [(3,4-dimethoxyphenyl)methyl] -6,7-
propanoyloxy] pentyl 3- [(1"R",2"R")-1- [(3,4-dimethoxy
width = 300
CAS_number = 96946-42-8
ATC_prefix = M03
ATC_suffix = AC11
PubChem = 62887
DrugBank = APRD00874
C = 53 | H = 72 | N = 2 | O = 12 | charge = +2
molecular_weight = 929.145 g/mol
bioavailability = N/A - IV use only
protein_bound = Unknown due to rapid degradation
metabolism = 80% Hoffman elmination/ Hepatic
elimination_half-life = 20-29 minutes
excretion = 10-15% unchanged
pregnancy_category = B
routes_of_administration = IV only
Cisatracurium (usually as cisatracurium besilate, trade name Nimbex) is a
neuromuscular-blocking drug. It is one of the ten isomersof atracurium. Its active metabolitescontain less laudanosinewhich cause hypotension, central nervous system excitement, and seizures than that of atracurium. It is considered an intermediate-acting agent in terms of duration of action.
It is a bisbenzyltetrahyrdoisoquinolinium agent in the
quaternary ammonium compoundfamily.
80% is metabolized to
laudanosinevia Hofmann elimination(which is dependent on the pHand the temperature of the plasma) and 20% is metabolized hepatically or excreted renally. Since Hofmann elimination is organ-independent, the use of cisatracurium may pose less risk in patients with liver or renal disease than other neuromuscular blockers. 10-15% of the dose is excreted unchanged in the urine.
Wikimedia Foundation. 2010.