Triclabendazole

Drugbox
IUPAC_name = 5-chloro-6- (2,3-dichlorophenoxy) -2-methylsulfanyl- 3H-benzoimidazole

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CAS_number=68786-66-3
ATC_prefix=P02
ATC_suffix=BX04
PubChem=50248
DrugBank=
C=14 | H=9 | Cl=3 | N=2 | O=1 | S=1
molecular_weight = 359.658
bioavailability= ?
metabolism = oxidation to the sulfone and sulfoxide parent compound
elimination_half-life= 22 - 24 hs
excretion = >95% in faeces, 2% in urine, and < 1% in milk
pregnancy_category = ?
legal_status = ?
routes_of_administration= ?

Triclabendazole (commercial name Fasinex) is a member of the Benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group.

Triclabendazole displays high efficacy against both immature and adult liver fluke.

It is generally accepted that benzimidazoles like triclabendazole bind to beta-tubulin and prevent the polymerisation of the microtubules of which they are part.

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