Profenamine

Profenamine
Profenamine
Systematic (IUPAC) name
N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Pharmacokinetic data
Protein binding 93%
Half-life 1 to 2 hours
Identifiers
CAS number 1094-08-2 YesY
ATC code N04AA05
PubChem CID 3290
DrugBank APRD00729
ChemSpider 3174 YesY
UNII O00T1I1VRN YesY
ChEBI CHEBI:313639 N
ChEMBL CHEMBL1206 YesY
Chemical data
Formula C19H24N2S 
Mol. mass 312.473 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Profenamine (Parsidol, Parsidan, Parkin), also known as ethopropazine, is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.

Chemistry

Ethopropazine, 10-(2-diethylaminopropyl) phenothiazine, is synthesized by alkylation of phenothiazine using 1-diethylamino-2-propylchloride in the presence of sodium amide.

Ethopropazine synthesis.png

References