- SR 59230A
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ImageFile=SR 59230A.svg
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IUPACName=(2"S")-1-(2-ethylphenoxy)-3-{ [(1"S")-1,2,3, 4-tetrahydronaphthalen-1-yl] amino}propan-2-ol
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Section1=Chembox Identifiers
CASNo=174689-39-5
PubChem=5311452
SMILES=CCC1=CC=CC=C1OCC(CNC2CCCC3=CC=CC=C23)O
Section2=Chembox Properties
C=21|H=27|N=1|O=2
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Autoignition=SR 59230A is a selective antagonist of the
beta-3 adrenergic receptor .cite journal | author = Nisoli E, Tonello C, Landi M, Carruba MO | title = Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes | journal = Mol. Pharmacol. | volume = 49 | issue = 1 | pages = 7–14 | year = 1996 | pmid = 8569714 | doi = | issn = ] cite journal |author=Bellantuono V, Cassano G, Lippe C |title=The adrenergic receptor subtypes present in frog (Rana esculenta) skin |journal=Comp. Biochem. Physiol. C Toxicol. Pharmacol. |volume=148 |issue=2 |pages=160–4 |year=2008 |month=August |pmid=18544474 |doi=10.1016/j.cbpc.2008.05.001 |url=http://linkinghub.elsevier.com/retrieve/pii/S1532-0456(08)00076-8] cite journal |author=Rickenbacher A, Seiler R, Honegger U, Shaw SG, Balsiger BM |title=Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation |journal=Surgery |volume=143 |issue=1 |pages=94–102 |year=2008 |month=January |pmid=18154937 |doi=10.1016/j.surg.2007.06.034 |url=http://linkinghub.elsevier.com/retrieve/pii/S0039-6060(07)00443-6]Although it is usually considered a selective agent, some have questioned this categorization.cite journal |author=Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B |title=Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery |journal=J. Pharmacol. Exp. Ther. |volume=309 |issue=1 |pages=137–45 |year=2004 |month=April |pmid=14718590 |doi=10.1124/jpet.103.061192 |url=http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=14718590]
References
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