Epinephrine

Epinephrine
"Adrenaline" and "Adrenalin" redirect here. For other uses, see Adrenaline (disambiguation).
(R)-(–)-L-Epinephrine or (R)-(–)-L-adrenaline
Systematic (IUPAC) name
(R)-4-(1-hydroxy-
2-(methylamino)ethyl)benzene-1,2-diol
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a603002
Pregnancy cat. A(AU) C(US)
Legal status Prescription Only (S4) (AU) POM (UK) ℞-only (US)
Routes IV, IM, endotracheal, IC
Pharmacokinetic data
Bioavailability Nil (oral)
Metabolism adrenergic synapse (MAO and COMT)
Half-life 2 minutes
Excretion Urine
Identifiers
CAS number 51-43-4 YesY
ATC code A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01
PubChem CID 5816
IUPHAR ligand 509
DrugBank DB00668
ChemSpider 5611 YesY
UNII YKH834O4BH YesY
KEGG D00095 YesY
ChEBI CHEBI:28918 YesY
ChEMBL CHEMBL679 YesY
Chemical data
Formula C9H13NO3 
Mol. mass 183.204 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Epinephrine (also known as adrenaline) is a hormone and a neurotransmitter.[1] It increases heart rate, constricts blood vessels, dilates air passages and participates in the fight-or-flight response of the sympathetic nervous system.[2] Chemically, adrenaline is a catecholamine, a monoamine produced only by the adrenal glands from the amino acids phenylalanine and tyrosine.

The term adrenaline is derived from the Latin roots ad- and renes and literally means "on the kidney", in reference to the adrenal gland's anatomic location on the kidney. The Greek roots epi means on top of, while "Nephros" refers to the kidneys. These roots combined create adrenaline which roughly translates to "pertaining to on top of the kidneys" which is also the anatomical location of the adrenal glands. The term epinephrine is often shortened to epi in medical jargon.[3]

Adrenal extracts containing adrenaline were first obtained by Polish physiologist Napoleon Cybulski in 1895. These extracts, which he called nadnerczyna, contained adrenaline and other catecholamines.[4] Japanese chemist Jokichi Takamine and his assistant Keizo Uenaka independently discovered adrenaline in 1900.[5][6] In 1901, Takamine successfully isolated and purified the hormone from the adrenal glands of sheep and oxen.[7] Adrenaline was first synthesized in the laboratory by Friedrich Stolz and Henry Drysdale Dakin, independently, in 1904.[6]

Contents

Medical uses

Epinephrine ampule, 1 mg (Suprarenin)

Adrenaline is used to treat a number of conditions including: cardiac arrest, anaphylaxis,and superficial bleeding.[8] It has been used historically for bronchospasm and hypoglycemia, but better treatments for these, such as salbutamol and dextrose respectively, are now preferred.[8]

Cardiac arrest

Adrenaline is used as a drug to treat cardiac arrest and other cardiac dysrhythmias resulting in diminished or absent cardiac output. Its actions are to increase peripheral resistance via α1receptor-dependent vasoconstriction and to increase cardiac output via its binding to β1 receptors. The usual ACLS concentration for injection is 1 mg adrenaline 1:10,000 every 3 - 5 minutes for adults or 0.01 mg/kg for pediatrics.

Anaphylaxis

Due to its vasoconstrictive effects, adrenaline is the drug of choice for treating anaphylaxis. It is also useful in treating sepsis. Allergy[9] patients undergoing immunotherapy may receive an adrenaline rinse before the allergen extract is administered, thus reducing the immune response to the administered allergen. It is also used as a bronchodilator for asthma if specific β2 agonists are unavailable or ineffective.[10]

Because of various expressions of α1 or β2 receptors, depending on the patient, administration of adrenaline may raise or lower blood pressure, depending on whether or not the net increase or decrease in peripheral resistance can balance the positive inotropic and chronotropic effects of adrenaline on the heart, effects which respectively increase the contractility and rate of the heart.[citation needed]

The usual concentration for SQ or IM injection is 0.3 - 0.5 mg 1:1,000.

Croup

Racemic epinephrine has historically been used for the treatment of croup.[11][12] Racemic adrenaline is a 1:1 mixture of the dextrorotatory (D) and levorotatory (L) isomers of adrenaline.[13] The L form is the active component.[13] Racemic adrenaline works by stimulation of the α-adrenergic receptors in the airway with resultant mucosal vasoconstriction and decreased subglottic edema and by stimulation of the β-adrenergic receptors with resultant relaxation of the bronchial smooth muscle.[12]

In local anesthetics

Adrenaline is added to injectable forms of a number of local anesthetics, such as bupivacaine and lidocaine, as a vasoconstrictor to retard the absorption and therefore prolong the action of the anesthetic agent. Some of the adverse effects of local anesthetic use, such as apprehension, tachycardia and tremor, may be caused by adrenaline.[14]

Autoinjectors

Adrenaline is available in an autoinjector delivery system. EpiPens, Anapens and Twinjects all use adrenaline as their active ingredient. Twinjects contain a second dose of adrenaline in a separate syringe and needle delivery system contained within the body of the autoinjector.

Though both EpiPen and Twinject are trademark names, common usage of the terms is drifting toward the generic context of any adrenaline autoinjector.[citation needed]

Adverse effects

Adverse reactions to adrenaline include palpitations, tachycardia, arrhythmia, anxiety, headache, tremor, hypertension, and acute pulmonary edema.[15]

Use is contraindicated in people on nonselective β-blockers, because severe hypertension and even cerebral hemorrhage may result.[16] Although commonly believed that administration of adrenaline may cause heart failure by constricting coronary arteries, this is not the case. Coronary arteries only have β2 receptors, which cause vasodilation in the presence of adrenaline.[17] Even so, administering high-dose adrenaline has not been definitively proven to improve survival or neurologic outcomes in adult victims of cardiac arrest.[18]

Measurement in biological fluids

Adrenaline may be quantitated in blood, plasma or serum as a diagnostic aid, to monitor therapeutic administration or to identify the causative agent in a potential poisoning victim. Endogenous plasma adrenaline concentrations in resting adults are normally less than 10 ng/L, but may increase by 10-fold during exercise and by 50-fold or more during times of stress. Pheochromocytoma patients often have plasma adrenaline levels of 1000-10,000 ng/L. Parenteral administration of adrenaline to acute-care cardiac patients can produce plasma concentrations of 10,000 to 100,000 ng/L.[19][20]

Mechanism of action

See also: Adrenergic receptor

As a hormone, adrenaline acts on nearly all body tissues. Its actions vary by tissue type and tissue expression of adrenergic receptors. For example, adrenaline causes smooth muscle relaxation in the airways but causes contraction of the smooth muscle that lines most arterioles.

Adrenaline acts by binding to a variety of adrenergic receptors. Adrenaline is a nonselective agonist of all adrenergic receptors, including α1, α2, β1, β2, and β3 receptors.[16] Epinephrine's binding to these receptors triggers a number of metabolic changes. Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis in muscle.[21] β-adrenergic receptor binding triggers glucagon secretion in the pancreas, increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland, and increased lipolysis by adipose tissue. Together, these effects lead to increased blood glucose and fatty acids, providing substrates for energy production within cells throughout the body.[21]

In addition to these metabolic changes, epinephrine also leads to broad alterations throughout all organ systems.

Physiologic responses to epinephrine by organ
Organ Effects
Heart Increases heart rate
Lungs Increases respiratory rate
Nearly all tissues Vasoconstriction or vasodilation
Liver Stimulates glycogenolysis
N/A, systemic Triggers lipolysis
N/A, systemic Muscle contraction

Biosynthesis and regulation

Adrenaline is synthesized in the medulla of the adrenal gland in an enzymatic pathway that converts the amino acid tyrosine into a series of intermediates and, ultimately, adrenaline. Tyrosine is first oxidized to L-DOPA, which is subsequently decarboxylated to give dopamine. Oxidation gives norepinephrine, which is methylated to give epinephrine.

Adrenaline is synthesized via methylation of the primary distal amine of noradrenaline by phenylethanolamine N-methyltransferase (PNMT) in the cytosol of adrenergic neurons and cells of the adrenal medulla (so-called chromaffin cells). PNMT is only found in the cytosol of cells of adrenal medullary cells. PNMT uses S-adenosylmethionine (SAMe) as a cofactor to donate the methyl group to noradrenaline, creating adrenaline.[citation needed]

The biosynthesis of adrenaline involves a series of enzymatic reactions.

For noradrenaline to be acted upon by PNMT in the cytosol, it must first be shipped out of granules of the chromaffin cells. This may occur via the catecholamine-H+ exchanger VMAT1. VMAT1 is also responsible for transporting newly synthesized adrenaline from the cytosol back into chromaffin granules in preparation for release.[citation needed]

In liver cells, adrenaline binds to the β-adrenergic receptor, which changes conformation and helps Gs, a G protein, exchange GDP to GTP. This trimeric G protein dissociates to Gs alpha and Gs beta/gamma subunits. Gs alpha binds to adenyl cyclase, thus converting ATP into cyclic AMP. Cyclic AMP binds to the regulatory subunit of protein kinase A: Protein kinase A phosphorylates phosphorylase kinase. Meanwhile, Gs beta/gamma binds to the calcium channel and allows calcium ions to enter the cytoplasm. Calcium ions bind to calmodulin proteins, a protein present in all eukaryotic cells, which then binds to phosphorylase kinase and finishes its activation. Phosphorylase kinase phosphorylates glycogen phosphorylase, which then phosphorylates glycogen and converts it to glucose-6-phosphate.[citation needed]

Regulation

The major physiologic triggers of adrenaline release center upon stresses, such as physical threat, excitement, noise, bright lights, and high ambient temperature. All of these stimuli are processed in the central nervous system.[22]

Adrenocorticotropic hormone (ACTH) and the sympathetic nervous system stimulate the synthesis of adrenaline precursors by enhancing the activity of tyrosine hydroxylase and dopamine-β-hydroxylase, two key enzymes involved in catecholamine synthesis.[citation needed] ACTH also stimulates the adrenal cortex to release cortisol, which increases the expression of PNMT in chromaffin cells, enhancing adrenaline synthesis. This is most often done in response to stress.[citation needed] The sympathetic nervous system, acting via splanchnic nerves to the adrenal medulla, stimulates the release of adrenaline. Acetylcholine released by preganglionic sympathetic fibers of these nerves acts on nicotinic acetylcholine receptors, causing cell depolarization and an influx of calcium through voltage-gated calcium channels. Calcium triggers the exocytosis of chromaffin granules and thus the release of adrenaline (and noradrenaline) into the bloodstream.[citation needed]

Adrenaline (as with noradrenaline) does exert negative feedback to down-regulate its own synthesis at the presynaptic alpha-2 adrenergic receptor.[citation needed] Abnormally elevated levels of adrenaline can occur in a variety of conditions, such as surreptitious epinephrine administration, pheochromocytoma, and other tumors of the sympathetic ganglia.

Its action is terminated with reuptake into nerve terminal endings, some minute dilution, and metabolism by monoamine oxidase and catechol-O-methyl transferase.

Chemical synthesis

Epinephrine may be synthesized by the reaction of catechol with chloroacetyl chloride, followed by the reaction with methylamine to give the ketone, which is reduced to the desired hydroxy compound. The racemic mixture may be separated using tartaric acid.

Formula for the synthesis of adrenaline

For isolation from the adrenal glands tissue of livestock:

  • J. Takamine, J. Soc. Chem. Ind., 20, 746 (1901).
  • J. B. Aldrich, Am. J. Physiol., 5, 457 (1901).

Synthetic production:

  • A. F. Stolz, Chem. Ber., 37, 4149 (1904).
  • K. R. Payne, Ind. Chem. Chem. Manuf., 37, 523 (1961).
  • H. Loewe, Arzneimittel-Forsch., 4, 583 (1954).
  • Farbenwerke Meister Lucins & Bruning in Hochst a.M., DE 152814  (1903).
  • Farbenwerke Meister Lucins & Bruning in Hochst a.M., DE 157300  (1903).
  • Farbenwerke Meister Lucins & Bruning in Hochst a.M., DE 222451  (1908).
  • Tullar, B. F. (1948). "The resolution of dl-arterenol". Journal of the American Chemical Society 70 (6): 2067. doi:10.1021/ja01186a024. PMID 18863798.  edit
  • D. Flacher, Z. Physiol. Chem., 58, 189 (1908).

Adrenaline junkie

"Adrenaline junkie" redirects here. For the British reality TV series, see Jack Osbourne: Adrenaline Junkie.

Adrenaline junkie is a term used to describe somebody who appears to be addicted to epinephrine (endogenous), and such a person is sometimes described as getting a "high" from life. The term adrenaline junkie was popularly used in the 1991 movie Point Break to describe individuals who enjoyed dangerous activities (such as extreme sports, e.g. BASE jumping) for the adrenaline "rush". Adrenaline junkies appear to favor stressful activities for the release of epinephrine as a stress response. Whether or not the positive response is caused specifically by epinephrine is difficult to determine, as endorphins are also released during the fight-or-flight response to such activities.[23][24]

Terminology

This chemical is widely referred to as "adrenaline" outside of the United States; however, its United States Adopted Name and International Nonproprietary Name is epinephrine. Epinephrine was chosen because adrenaline bore too much similarity to the Parke, Davis & Co trademark Adrenalin (without the e), which was registered in the United States. The British Approved Name and European Pharmacopoeia term for this chemical is adrenaline and is indeed now one of the few differences between the INN and BAN systems of names.[25]

Amongst American health professionals and scientists, the term epinephrine is used over adrenaline. However, pharmaceuticals that mimic the effects of epinephrine are often called adrenergics, and receptors for epinephrine are called adrenergic receptors or adrenoceptors.

Notes

  1. ^ Berecek Kh, B. M.; Brody, M. J. (1982). "Evidence for a neurotransmitter role for epinephrine derived from the adrenal medulla". Am J Physiol 242 (4): H593–H601. PMID 6278965.  edit
  2. ^ Cannon, W. B. (1929). American Journal of Physiology 89: 84–107. [Full citation needed]
  3. ^ Gail Askew and Marilyn Smith-Stoner. (2001). The Pharmacy Assistant (Clinical Allied Heathcare Series). Clifton Park, NY: Thomson Delmar Learning. pp. 4–6. ISBN 0-89262-438-8. 
  4. ^ "Polish Thread in the History of Circulatory Physiology". http://www.jpp.krakow.pl/journal/archive/04_06_s1/articles/01_article.html. Retrieved 2011-04-24. 
  5. ^ Yamashima T (2003). "Jokichi Takamine (1854–1922), the samurai chemist, and his work on adrenalin". J Med Biogr 11 (2): 95–102. PMID 12717538. 
  6. ^ a b Bennett M (1999). "One hundred years of adrenaline: the discovery of autoreceptors". Clin Auton Res 9 (3): 145–59. doi:10.1007/BF02281628. PMID 10454061. 
  7. ^ Takamine J (1901). The isolation of the active principle of the suprarenal gland. Great Britain: Cambridge University Press. pp. xxix-xxx. http://books.google.com/?id=xVEq06Ym6qcC&pg=RA1-PR29#PRA1-PR29,M1. 
  8. ^ a b "Epinephrine". The American Society of Health-System Pharmacists. http://www.drugs.com/monograph/epinephrine.html. Retrieved 3 April 2011. 
  9. ^ Sicherer, Scott H. (2006). Understanding and Managing Your Child's Food Allergy. Baltimore: The Johns Hopkins University Press. ISBN 0801884918. 
  10. ^ "Asthma Causes, Types, Symptoms, Treatment, Medication, Facts and the Link to Allergies by MedicineNet.com". http://www.medicinenet.com/asthma/page8.htm. 
  11. ^ Bjornson CL, Johnson DW (2008). "Croup". The Lancet 371 (9609): 329–339. doi:10.1016/S0140-6736(08)60170-1. PMID 18295000. 
  12. ^ a b Thomas LP, Friedland LR (1998). "The cost-effective use of nebulized racemic adrenaline in the treatment of croup". American Journal of Emergency Medicine 16 (1): 87–89. doi:10.1016/S0735-6757(98)90073-0. PMID 9451322. 
  13. ^ a b Malhotra A, Krilov LR (2001). "Viral Croup". Pediatrics in Review 22 (1): 5–12. doi:10.1542/pir.22-1-5. PMID 11139641. 
  14. ^ R. Rahn and B. Ball. Local Anesthesia in Dentistry, 3M ESPE AG, ESPE Platz, Seefeld, Germany, 2001, 44 pp.
  15. ^ About.com - "The Definition of Epinephrine"
  16. ^ a b Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. pp. 4. ISBN 1-59541-101-1. 
  17. ^ Sun, D; Huang, A; Mital, S; Kichuk, MR; Marboe, CC; Addonizio, LJ; Michler, RE; Koller, A et al. (2002). "Norepinephrine elicits beta2-receptor-mediated dilation of isolated human coronary arterioles". Circulation 106 (5): 550–5. doi:10.1161/01.CIR.0000023896.70583.9F. PMID 12147535.  edit
  18. ^ Stiell, I. G.; Hebert, P. C.; Weitzman, B. N.; Wells, G. A.; Raman, S.; Stark, R. M.; Higginson, L. A. J.; Ahuja, J. et al. (1992). "High-Dose Epinephrine in Adult Cardiac Arrest". New England Journal of Medicine 327 (15): 1045. doi:10.1056/NEJM199210083271502. PMID 1522840.  edit
  19. ^ Raymondos, K.; Panning, B.; Leuwer, M.; Brechelt, G.; Korte, T.; Niehaus, M.; Tebbenjohanns, J.; Piepenbrock, S. (2000). "Absorption and hemodynamic effects of airway administration of adrenaline in patients with severe cardiac disease". Ann. Intern. Med. 132 (10): 800–803. PMID 10819703. 
  20. ^ Baselt, R. (2008). Disposition of Toxic Drugs and Chemicals in Man (8th ed.). Foster City, CA: Biomedical Publications. pp. 545–547. ISBN 0962652377. 
  21. ^ a b Sabyasachi Sircar (2007). Medical Physiology. Thieme Publishing Group. pp. 536. ISBN 3-13-144061-9. 
  22. ^ Nelson, L.; Cox, M. (2004). Lehninger Principles of Biochemstry (4th ed.). New York: Freeman. p. 908. ISBN 0716743396. 
  23. ^ What Is An Adrenaline Junkie? What Can You Do If You Are One? by Elizabeth Scott, M.S. (updated: November 1, 2007) About.com Health's Disease and Condition content is reviewed by the Medical Review Board.
  24. ^ Fight-or-flight reaction - Explanations - Brain - ChangingMinds.org.
  25. ^ http://www.mhra.gov.uk/Howweregulate/Medicines/Namingofmedicines/ChangestomedicinesnamesBANstorINNs/index.htm

References

  • Boron WF, Boulpaep EL (2005). Medical Physiology: A Cellular And Molecular Approach. Philadelphia, PA: Elsevier/Saunders. ISBN 1-4160-2328-3. OCLC 56191776. 
  • Voet D, Voet J (2004). Biochemistry (3rd ed.). USA: Wiley. ISBN 0-471-19350-x. OCLC 154657578. 

External links

v · d · ePhenethylamines
Phenethylamines
Psychedelics: 2C-B • 2C-B-FLY • 2C-C • 2C-D • 2C-E • 2C-F • 2C-G • 2C-I • 2C-N • 2C-P • 2C-SE • 2C-T • 2C-T-2 • 2C-T-4 • 2C-T-7 • 2C-T-8 • 2C-T-9 • 2C-T-13 • 2C-T-15 • 2C-T-17 • 2C-T-21 • 2C-TFM • 2C-YN • Allylescaline • DESOXY • Escaline • Isoproscaline • Jimscaline • Macromerine • MEPEA • Mescaline • Metaescaline • Methallylescaline • Proscaline • Psi-2C-T-4 • TCB-2
Stimulants: 2-OH-PEA • β-Me-PEA • Hordenine • N-Me-PEA • Phenethylamine (PEA)
Entactogens: Lophophine • MDPEA • MDMPEA
Others: BOH • DMPEA
Amphetamines
Phenylisopropylamines
Psychedelics: 3C-BZ • 3C-E • 3C-P • Aleph • Beatrice • Bromo-DragonFLY • D-Deprenyl • DMA • DMCPA • DMMDA • DOB • DOC • DOEF • DOET • DOI • DOM • DON • DOPR • DOTFM • Ganesha • MMDA • MMDA-2 • Psi-DOM • TMA • TeMA
Stimulants: 4-MA • 4-MMA • 4-MTA • 5-IT • Alfetamine • Amfecloral • Amfepentorex • Amphetamine (Dextroamphetamine, Levoamphetamine) • Amphetaminil • Benfluorex • Benzphetamine • Cathine • Clobenzorex • Dimethylamphetamine • Ephedrine (EPH) • Ethylamphetamine • Fencamfamine • Fencamine • Fenethylline • Fenfluramine (Dexfenfluramine) • Fenproporex • Fludorex • Furfenorex • Isopropylamphetamine • Lefetamine • Mefenorex • Methamphetamine (Dextromethamphetamine, Levomethamphetamine) • Methoxyphenamine • MMA • Norfenfluramine • Oxilofrine • Ortetamine • PBA • PCA • Phenpromethamine • PFA • PFMA • PIA • PMA • PMEA • PMMA • Phenylpropanolamine (PPA) • Prenylamine • Propylamphetamine • Pseudoephedrine (PSE) • Sibutramine • Tiflorex (Flutiorex) • Tranylcypromine • Xylopropamine • Zylofuramine
Entactogens: 5-APDB • 6-APB • 6-APDB • EDA • IAP • MDA • MDEA • MDHMA (FLEA) • MDMA ("Ecstasy") • MDOH • MMDMA • NAP • TAP
Others: Amiflamine • DFMDA • D-Deprenyl • L-Deprenyl (Selegiline)
Phentermines
Stimulants: Chlorphentermine • Cloforex • Clortermine • Etolorex • Mephentermine • Pentorex (Phenpentermine) • Phentermine
Entactogens: MDPH • MDMPH
Cathinones
Stimulants: Amfepramone • Brephedrone • Buphedrone • Bupropion (Amfebutamone) • Cathinone (Propion) • Dimethylcathinone (Dimethylpropion, Metamfepramone) • Ethcathinone (Ethylpropion) • Flephedrone • Methcathinone (Methylpropion) • Mephedrone • Methedrone
Entactogens: Ethylone • Methylone
Phenylisobutylamines
Entactogens: 4-CAB • 4-MAB • Ariadne (α-Et-DOM) • BDB (J) • Butylone (bk-MBDB) • EBDB (Ethyl-J) • Eutylone (bk-EBDB) • MBDB (Methyl-J)
Stimulants: Phenylisobutylamine
Phenylalkylpyrrolidines
Stimulants: α-PBP • α-PPP • α-PVP • MDPBP • MDPPP • MDPV • MOPPP • MPBP • MPHP • MPPP • Naphyrone • PEP • Prolintane • Pyrovalerone
Catecholamines
(and relatives..)
6-FNE • 6-OHDA • α-Me-DA • α-Me-TRA • Adrenochrome • Ciladopa • D-DOPA (Dextrodopa) • Dopamine • Epinephrine (Adrenaline) • Epinine • Fenclonine • Ibopamine • L-DOPA (Levodopa) • L-DOPS (Droxidopa) • L-Phenylalanine • L-Tyrosine • meta-Octopamine • meta-Tyramine • Metanephrine • Metirosine • Methyldopa • Nordefrin (Levonordefrin) • Norepinephrine (Noradrenaline) • Normetanephrine • para-Octopamine • para-Tyramine
Miscellaneous
Amidephrine • Arbutamine • Cafedrine • Denopamine • Dobutamine • Dopexamine • Etafedrine • Ethylnorepinephrine • Etilefrine • Famprofazone • Gepefrine • Isoprenaline (Isoproterenol) • Isoetarine • Metaraminol • Metaterol • Methoxamine • Norfenefrine • Orciprenaline • Phenylephrine (Neosynephrine) • Phenoxybenzamine • Prenalterol • Pronethalol • Propranolol • Salbutamol (Albuterol; Levosalbutamol) • Synephrine (Oxedrine) • Theodrenaline • Xamoterol
v · d · eCardiac stimulants excluding cardiac glycosides (C01C)
Adrenergic and
dopaminergic agents
α
β
mixed
Both
Unknown/ungrouped
Phosphodiesterase inhibitors (PDE3I)
Other cardiac stimulants

M: HRT

anat/phys/devp

noco/cong/tumr, sysi/epon, injr

proc, drug (C1A/1B/1C/1D), blte
v · d · eDrugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants
other
Glucocorticoids
Anticholinergics/
muscarinic antagonist
Ipratropium bromide# • Oxitropium bromide • Tiotropium bromide
Mast cell stabilizers
Cromoglicate • Nedocromil
Xanthines
Eicosanoid inhibition
Thromboxane receptor antagonists
Combination products

M: RES

anat(n, x, l, c)/phys/devp

noco(c, p)/cong/tumr, sysi/epon, injr

proc, drug(R1/2/3/5/6/7)
v · d · eAntihemorrhagics (B02)
Hemostatics
(coagulation)
Systemic

intrinsic: IX/Nonacog alfa • VIII

extrinsic: VII/Eptacog alfa

common: X • II/Thrombin • I/Fibrinogen
Other systemic
Etamsylate • Carbazochrome • Batroxobin • thrombopoietin receptor agonist (Romiplostim, Eltrombopag)
Local
Antifibrinolytics

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns
v · d · eHealth science > Medicine > Emergency medicine
Procedures
Equipment
Drugs
Atropine · Amiodarone · Epinephrine/Adrenaline · Magnesium Sulfate · Sodium Bicarbonate · Naloxone
Other
v · d · eNeurotransmitters
Amino acids

Alanine · Aspartate · Cycloserine · DMG · GABA · Glutamate · Glycine · Hypotaurine · Kynurenic acid (Transtorine) · NAAG (Spaglumic acid) · NMG (Sarcosine) · Serine · Taurine · TMG (Betaine)
Endocannabinoids

2-AG · 2-AGE (Noladin ether) · AEA (Anandamide) · NADA · OAE (Virodhamine) · Oleamide  · PEA (Palmitoylethanolamide)  · RVD-Hpα  · Hp (Hemopressin)
Gasotransmitters
Monoamines
Purines

Adenosine · ADP · AMP · ATP
Trace amines

3-ITA · 5-MeO-DMT · Bufotenin · DMT · NMT · Octopamine · Phenethylamine · Synephrine · Thyronamine · Tryptamine · Tyramine
Others

M: PNS

anat(h/r/t/c/b/l/s/a)/phys(r)/devp/prot/nttr/nttm/ntrp

noco/auto/cong/tumr, sysi/epon, injr

proc, drug(N1B)


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • épinéphrine — ● épinéphrine nom féminin (grec nephros, rein) Synonyme de adrénaline. ● épinéphrine (synonymes) nom féminin (grec nephros, rein) Synonymes : adrénaline …   Encyclopédie Universelle

  • epinephrine — 1883, from EPI (Cf. epi ) “upon” + Gk. nephros “kidney” (see NEPHRON (Cf. nephron)) + chemical suffix INE (Cf. ine) (2). So called because the adrenal glands are on the kidneys …   Etymology dictionary

  • epinephrine — ☆ epinephrine [ep΄ə nef′rin, ep΄ə nef′rēn΄ ] n. [ EPI + NEPHR(O) + INE3] a hormone, C9H13NO3, secreted by the medulla of the adrenal gland, that stimulates the heart, increases blood sugar, muscular strength, and endurance, etc.; adrenaline: it… …   English World dictionary

  • Epinéphrine — Adrénaline Pour les articles homonymes, voir Adrénaline (homonymie). Adrénaline …   Wikipédia en Français

  • Épinéphrine — Adrénaline Pour les articles homonymes, voir Adrénaline (homonymie). Adrénaline …   Wikipédia en Français

  • Epinephrine — A substance produced by the medulla (inside) of the adrenal gland. The name epinephrine was coined in 1898 by the American pharmacologist and physiologic chemist (biochemist) John Jacob Abel who isolated it from the adrenal gland which is located …   Medical dictionary

  • epinephrine — /ep euh nef rin, reen/, n. 1. Biochem. a hormone secreted by the adrenal medulla upon stimulation by the central nervous system in response to stress, as anger or fear, and acting to increase heart rate, blood pressure, cardiac output, and… …   Universalium

  • epinephrine — adrenalinas statusas T sritis chemija apibrėžtis Hormonas. formulė (HO)₂C₆H₃CH(OH)CH₂NHCH₃ atitikmenys: angl. adrenalin; adrenaline; epinephrine rus. адреналин; эпинефрин ryšiai: sinonimas – epinefrinas sinonimas – 4 (1 hidroksi 2 metilaminoetil) …   Chemijos terminų aiškinamasis žodynas

  • Epinephrine autoinjector — An old version of a 0.3 mg EpiPen auto injector An epinephrine autoinjector is a medical device used to deliver a measured dose (or doses) of epinephrine (also known as adrenaline) using autoinjector technology, most frequently for the treatment… …   Wikipedia

  • epinephrine and norepinephrine — ▪ hormone also called  adrenaline  and  noradrenaline,   two separate but related hormones secreted by the medulla of the adrenal glands (adrenal gland). They are also produced at the ends of sympathetic nerve fibres, where they serve as chemical …   Universalium

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”