- 2C-TFM
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IUPACName = 2,5-Dimethoxy-4-(trifluoromethyl)phenethylamine
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Section1 = Chembox Identifiers
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SMILES = COc1cc(CCN)c(cc1C(F)(F)F)OC
Section2 = Chembox Properties
Formula = C11H14F3NO2
MolarMass = 249.23 g/mol
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MeltingPt = 260 °C (hydrochloride )
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Autoignition =2C-TFM is a
psychedelic phenethylamine of the 2C family. It was first synthesized in the laboratory ofDavid E. Nichols . It has also been called 2C-CF3, a name derived from thepara- trifluoromethyl group it contains. It is sometimes used as a hallucinogen andentheogen .Chemistry
2C-TFM is a code that represents 4-tri
fluoro methyl -2,5-dimethoxy phenethylamine . The full name of the chemical is 2- [2,5-dimethoxy-4-(trifluoromethyl)phenyl] ethanamine.Dosage
A psychedelic dosage of 2C-TFM is reported to be 3-5 mg.
Effects
Very little data exists, but some reports suggest 2C-TFM produces hallucinogenic, psychedelic, and entheogenic effects that may last 6-8 hours.
Legality
2C-TFM is unscheduled and uncontrolled in the United States, but possession and sales of 2C-TFM will probably be prosecuted under the
Federal Analog Act because of its structural similarities to2C-B and2C-T-7 . However, 2C-TFM, unlike many otherphenethylamines , has not been widely sold by internet retailers. In the wake ofOperation Web Tryp in July 2004, the issue of possession and sales of 2C-TFM and other similar chemicals will probably be resolved in the courtroom as well the fate of this rare but uniquepsychedelic . There have been no reported deaths or hospitalizations from 2C-TFM.Pharmacology
The mechanism that produces the hallucinogenic and entheogenic effects of 2C-TFM is most likely to result from action as a 5-HT2A serotonin receptor
agonist in the brain, a mechanism of action shared by all of the hallucinogenictryptamines andphenethylamines . 2C-TFM displaced radiolabelledketanserin from 5-HT2A/C receptors with a Ki of 74.5, as compared to a Ki of 80.9 for the more well known 5-HT2A agonist DOI, indicating similar binding affinity at the receptor. [Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Grudelsky GA, Nash JF. 1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl-)2-aminopropane: A Potent Serotonin 5-HT2A/C agonist. J. Med. Chem. 1994, 37, 4346-4351.]Dangers
The toxicity of 2C-TFM is not known.
Popularity
Sale of 2C-TFM is unknown on the black market. Limited accounts of 2C-TFM can be found on the internet. Outside of David Nichols' lab, the only widely available black market 2C-TFM is known to have been less than 50% pure, with the majority of the impurity being unreacted
2C-I , as well as some undetermined minor constituents. [ [http://www.bluelight.ru/vb/showpost.php?p=3301660&postcount=81 Bluelight - View Single Post - The Big and Dandy 2C-TFM Thread ] ] Rs|date=May 2008References
External links
* [http://www.bluelight.ru/vb/showthread.php?t=190320&highlight=2ctfm 2C-TFM information from www.bluelight.ru]
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