- 6-Hydroxydopamine
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ImageFile=6-Hydroxydopamine.png
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IUPACName=5-(2-Aminoethyl)benzene-1,2,4-triol
OtherNames=6-Hydroxydopamine
Section1= Chembox Identifiers
CASNo=636-00-0
PubChem=4624
SMILES=NCCc1cc(O)c(O)cc1O
Section2= Chembox Properties
Formula=C8H11N1O3
MolarMass=169.178
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Section3= Chembox Hazards
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Autoignition=6-Hydroxydopamine, or 6-OHDA, is a neurotoxin used by neurobiologists to selectively kill
dopaminergic andnoradrenergic neurons. 6-OHDA enters the neurons via thedopamine and noradrenaline (ornorepinephrine ) reuptake transporters. 6-OHDA is often used in conjunction with a selective noradrenaline reuptake inhibitor (such asdesipramine ) to selectively kill dopaminergic neurons only. The reverse is also possible, however it is rarely done in research.The main use for 6-OHDA in scientific research is to induce
Parkinsonism in laboratory animals such as mice, rats and monkeys, in order to develop and test new medicines for treatingParkinson's disease in humans. In order to induce this condition in animals, around 90% of the dopaminergic neurons in thesubstantia nigra of the brain must be destroyed, and this is achieved either with 6-OHDA orMPTP . Both these agents likely destroy neurons by generating active oxygen species such assuperoxide radical. 6-OHDA toxicity in neonatal rodents is also used as an animal model for theLesch-Nyhan syndrome . [cite journal |author=Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake BL |title=The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles |journal=Brain Res. Brain Res. Rev. |volume=48 |issue=1 |pages=57–73 |year=2005 |pmid=15708628 |doi=10.1016/j.brainresrev.2004.08.004]References
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