Betamethasone Systematic (IUPAC) name (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one Clinical data Trade names Celestone AHFS/Drugs.com Pregnancy cat. C(US) Legal status ℞ Prescription only Routes oral or topical Pharmacokinetic data Bioavailability ? Metabolism hepatic CYP3A4 Half-life 5.6 hours Excretion Renal (in urine) Identifiers CAS number ATC code A07 C05 D07 D07 H02 R01 R03 S01 S01 S02 S03 PubChem DrugBank ChemSpider UNII KEGG ChEBI ChEMBL Chemical data Formula C22H29FO5 Mol. mass 392.461 SMILES & (what is this?)
Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments including allergic reactions to poison ivy and similar plants.
Betamethasone is available in a number of compound forms: betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, and others), sodium phosphate (branded as Bentelan in Italy) and valerate (branded as Betnovate, Celestone and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm.
Betamethasone is a corticosteroid used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as Betamethasone dipropionate and salicylic acid, or as the combination betamethasone/calcipotriol. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids.
A cream with 0.05% betamethasone appears effective in treating phimosis in boys, and often averts the need for circumcision.  It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.
Betamethasone is also used to stimulate fetal lung maturation (prevention of IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.
As it crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero.
- ^ http://farmaco.agenziafarmaco.it/index.php?SEARCH=yes&DESCR_SPECIALITA2=BENTELAN
- ^ Van Howe RS (1998). "Cost-effective treatment of phimosis". Pediatrics 102 (4): E43. doi:10.1542/peds.102.4.e43. PMID 9755280. http://pediatrics.aappublications.org/cgi/content/full/102/4/e43. A review of estimated costs and complications of 3 phimosis treatments.
- ^ Topical steroid application versus circumcision in pediatric patients with phimosis: a prospective randomized placebo controlled clinical trial, World Journal of Urology, 2008, 26, pp.187-190
- ^ Phimosis and topical steroids: new clinical findings, Pediatric Surgery International, 2007, 23, pp.331-335
- ^ Berdeu D, Sauze L, Ha-Vinh P, Blum-Boisgard C (2001). "Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect". BJU Int. 87 (3): 239–44. doi:10.1046/j.1464-410x.2001.02033.x. PMID 11167650. http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=1464-4096&date=2001&volume=87&issue=3&spage=239.
- ^ Chu CC, Chen KC, Diau GY (1999). "Topical steroid treatment of phimosis in boys". J. Urol. 162 (3 Pt 1): 861–3. doi:10.1097/00005392-199909010-00078. PMID 10458396.
- "Betamethasone". safefetus.com. http://www.safefetus.com/DrugDetail.asp?DrugId=709&TradeName=Betaval&TradeId=775.
Antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07) Rehydration Intestinal anti-infectives
Arsenical (Acetarsol)Oxyquinoline (Broxyquinoline)
Intestinal adsorbents Antipropulsives (opioids) Intestinal anti-inflammatory agents Antidiarrheal micro-organisms Other antidiarrheals Vasoprotectives (C05) Antihemorrhoidals for topical use Antivaricose therapy Capillary stabilising agents Decongestants and other nasal preparations (R01) TopicalSympathomimetics, plainAntiallergic agents,
excluding corticosteroidsOther nasal preparations
Drugs for obstructive airway diseases: asthma/COPD (R03) Adrenergics, inhalantsLong acting β2-agonists (LABA)other Glucocorticoids Anticholinergics/
Mast cell stabilizersCromoglicate • Nedocromil Xanthines Eicosanoid inhibitionThromboxane receptor antagonists Combination products Otologicals (S02) Anti-infectives Corticosteroids Analgesics and anesthetics
Wikimedia Foundation. 2010.