Betamethasone

Betamethasone
Betamethasone
Systematic (IUPAC) name
(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro- 3H-cyclopenta[a]phenanthren-3-one
Clinical data
Trade names Celestone
AHFS/Drugs.com monograph
Pregnancy cat. C(US)
Legal status Prescription only
Routes oral or topical
Pharmacokinetic data
Bioavailability  ?
Metabolism hepatic CYP3A4
Half-life 5.6 hours
Excretion Renal (in urine)
Identifiers
CAS number 378-44-9
ATC code A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
PubChem CID 9782
DrugBank APRD00513
ChemSpider 9399 YesY
UNII 9842X06Q6M YesY
KEGG D00244 YesY
ChEBI CHEBI:3077 YesY
ChEMBL CHEMBL632 YesY
Chemical data
Formula C22H29FO5 
Mol. mass 392.461
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments including allergic reactions to poison ivy and similar plants.

Contents

Forms

Betamethasone is available in a number of compound forms: betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, and others), sodium phosphate (branded as Bentelan in Italy[1]) and valerate (branded as Betnovate, Celestone and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm.

Indications

Betamethasone is a corticosteroid used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as Betamethasone dipropionate and salicylic acid, or as the combination betamethasone/calcipotriol. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids.

A cream with 0.05% betamethasone appears effective in treating phimosis in boys, and often averts the need for circumcision. [2][3][4] It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.[5][6]

Betamethasone is also used to stimulate fetal lung maturation (prevention of IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.

As it crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero[citation needed].

References

External links


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Look at other dictionaries:

  • Betamethasone — Bétaméthasone Bétaméthasone Général No CAS …   Wikipédia en Français

  • Bétaméthasone — Général No CAS …   Wikipédia en Français

  • bêtaméthasone — ● bêtaméthasone nom féminin Glucocorticoïde synthétique dérivé fluoré de la deltahydrocortisone, possédant un pouvoir anti inflammatoire et antiallergique élevé …   Encyclopédie Universelle

  • Betamethasone/calcipotriol — Combination of Betamethasone Glucocorticoid Calcipotriol Vitamin D analogue Clinical data Pregnancy cat. C Legal status ℞ Presc …   Wikipedia

  • betamethasone acetate — [USP] the acetate ester of betamethasone, having the same actions as the base; administered parenterally in combination with betamethasone sodium phosphate as an antiinflammatory and immunosuppressant …   Medical dictionary

  • betamethasone sodium phosphate — [USP] the disodium salt of the 21 phosphate ester of betamethasone, having the same actions as the base; used intramuscularly in the treatment of adrenocortical insufficiency and parenterally, alone or in combination with betamethasone acetate,… …   Medical dictionary

  • betamethasone benzoate — [USP] the 17 benzoate ester of betamethasone, having the same actions as the base; used topically for the relief of inflammation and pruritus in corticosteroid responsive dermatoses …   Medical dictionary

  • betamethasone dipropionate — [USP] the 17,21 dipropionate ester of betamethasone, having the same actions as the base; used topically for the relief of inflammation and pruritus in corticosteroid responsive dermatoses …   Medical dictionary

  • betamethasone valerate — [USP] the 17 valerate ester of betamethasone, used topically for the relief of inflammation and pruritus in corticosteroid responsive dermatoses …   Medical dictionary

  • betamethasone — /bay teuh meth euh sohn / or, esp. Brit., /bee /, n. Pharm. a synthetic analogue of a glucocorticoid, C22H29FO5, used in various forms in the treatment of inflammation, allergies, and tumors, and for replacement therapy in adrenal insufficiency.… …   Universalium

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