Nifuroxazide

Nifuroxazide
Nifuroxazide
Systematic (IUPAC) name
4-Hydroxy-N'-[(5-nitrofuran-2-yl)methylene]benzohydrazide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Routes Oral
Identifiers
CAS number 965-52-6 YesY
ATC code A07AX03
PubChem CID 5337997
ChemSpider 4495115 YesY
UNII PM5LI0P38J N
KEGG D07111 YesY
ChEMBL CHEMBL244888 YesY
Chemical data
Formula C12H9N3O5 
Mol. mass 275.2 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Nifuroxazide (INN) is an oral nitrofuran antibiotic, patented since 1966[1] and used to treat colitis and diarrhea in humans and non-humans.[2] It is sold under the brand names Ambatrol, Antinal, Bacifurane, Diafuryl (FR), Nifrozid, Ercefuryl, Erfuzide (TH), Endiex,Endiaron, Ercefurin,Nifuroksazyd (CZ, SK, PL), Pérabacticel (FR), Pentofuryl (DE) Enteral (Afrique Norte) and Septidiaryl. It is sold in capsule form and also as a suspension. The pharmaceutical group SmithKline Beecham claims that nifuroxazide is highly effective and the consumers' group Healthy Skepticism says that SmithKline Beecham's claims have no scientific support.[3]

Contents

History

Maurice Claude Ernest Carron patented the drug in the United States in 1966 [1]. Subsequent patents issued to Germano Cagliero of Marxer S.p.A describe the use of nifuroxazide as an antibiotic used to treat livestock.[2]

Effectiveness in humans

In 1997, in an Ivory Coast promotional leaflet, SmithKline Beecham claimed that nifuroxazide (under the brand name "Ambatrol") is an anti-dehydration treatment, "neutralise[s] microbacterials" in diarrhoea, and has "a spectrum which covers most enteropathogenic microbacterials, Shigella, Escherichia Coli, Salmonella, Staphylococci, Klebsiella, Yersinia".[3] The international non-profit organisation Healthy Skepticism, at the time using their former name, Medical Lobby for Appropriate Marketing (MaLAM), disagreed, stating "We have not found any scientific evidence to support these claims."[3]

Notes

  1. ^ a b USPTO No. 3290213 |http://www.google.com/patents?id=f2dwAAAAEBAJ
  2. ^ a b USPTO No 4093746 |http://www.google.com/patents?vid=USPAT4093746
  3. ^ a b c "SmithKline Beecham Ambatrol (nifuroxazide)". Healthy Skepticism. 1997-06. Archived from the original on 2010-12-21. http://www.healthyskepticism.org/global/malam/int/mi1997-05_06/. Retrieved 2010-12-21. 
v · d · eAntidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07)
Rehydration
Intestinal anti-infectives
Intestinal adsorbents
Antipropulsives (opioids)
Intestinal anti-inflammatory agents
Antidiarrheal micro-organisms
Other antidiarrheals

M: DIG

anat(t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug(A2A/2B/3/4/5/6/7/14/16), blte

External links


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