Tetracaine

Tetracaine

drugbox
IUPAC_name = 2-(dimethylamino)ethyl 4-(butylamino)benzoate


CAS_number = 94-24-6
CAS_supplemental = CAS|136-47-0 (hydrochloride)
ATC_prefix = C05
ATC_suffix = AD02
ATC_supplemental = ATC|D04|AB06 ATC|N01|BA03 ATC|S01|HA03
PubChem = 5411
DrugBank =
C = 15 | H = 24 | N = 2 | O = 2
molecular_weight = 264.363 g/mol
bioavailability =
protein_bound = 75.6
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration = Topical, Epidural, Spinal

Tetracaine (INN, also known as amethocaine; trade name Pontocaine) is a potent local anesthetic of the ester group. It is mainly used topically, in ophthalmology and as an antipruritic, and has been used in spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptor) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely [Györke, S., V. Lukyanenko, et al. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes. J Physiol 1997;500(Pt 2):297-309.] .

References

1. Györke, S., V. Lukyanenko, et al. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes. J Physiol 1997;500(Pt 2):297-309.

Faisal Al-Otaibi


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Look at other dictionaries:

  • Tetracaine — Tétracaïne Tétracaïne Général Nom IUPAC 2 (dimethylamino)ethyl 4 (butylamino)benzoate No CAS …   Wikipédia en Français

  • Tétracaïne — Général Nom IUPAC 4 (butylamino)benzoate de 2 (diméthylamino)éthyle No CAS …   Wikipédia en Français

  • tétracaïne — ● tétracaïne nom féminin Substance anesthésique utilisée à l état de chlorhydrate pour l anesthésie locale …   Encyclopédie Universelle

  • tetracaine hydrochloride — A highly potent local anesthetic used for spinal, nerve block, and topical anesthesia. * * * [USP] the hydrochloride salt of tetracaine, applied topically to the conjunctiva, to the mucous membranes of the nose, throat, and respiratory tract, and …   Medical dictionary

  • tetracaine — noun Etymology: tetra + caine Date: circa 1935 a crystalline basic ester C15H24N2O2 that is closely related chemically to procaine and is used chiefly in the form of its hydrochloride as a local anesthetic …   New Collegiate Dictionary

  • tetracaine — (= amethocaine) Potent local anaesthetic …   Dictionary of molecular biology

  • tetracaine — /te treuh kayn /, n. Pharm. a white, water soluble, crystalline solid, C15H24N2O2, used chiefly as an anesthetic. [1930 35; TETRA + (PRO)CAINE] * * * …   Universalium

  • tetracaine — noun A local anesthetic 2 (dimethylamino)ethyl 4 (butylamino)benzoate used in opthalmology Syn: amethocaine …   Wiktionary

  • tetracaine — tet·ra·caine te trə .kān n a crystalline basic ester that is closely related chemically to procaine and is used chiefly in the form of its hydrochloride C15H24N2O2·HCl as a local anesthetic called also amethocaine, pantocaine see PONTOCAINE …   Medical dictionary

  • tetracaine — n. substance used as a local anesthetic …   English contemporary dictionary

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