Oxetacaine

Oxetacaine
Oxetacaine
Systematic (IUPAC) name
2,2'-(2-hydroxyethylimino)bis [N-(1,1-dimethyl-2- phenylethyl)-N-methylacetamide]
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Routes Oral, topical
Pharmacokinetic data
Half-life 1 hour
Identifiers
CAS number 126-27-2 YesY
ATC code C05AD06
PubChem CID 4621
ChemSpider 4460 YesY
UNII IP8QT76V17 N
KEGG D01152 YesY
ChEMBL CHEMBL127592 YesY
Chemical data
Formula C28H41N3O3 
Mol. mass 467.643 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Oxetacaine (INN, also known as oxethazaine) is a potent local anesthetic. It is administered orally (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. It is also used topically in the management of hemorrhoid pain. Oral oxetacaine preparations are available in several countries, including India, South Africa, Japan and Brazil, but not the United States; oxetacaine was withdrawn from the UK market in 2002.

Unlike most local anesthetics, oxetacaine is active even in strongly acidic conditions.[1]

References

  1. ^ Seifter J, Glassman JM, Hudyma GM (1962). "Oxethazaine and related congeners: a series of highly potent local anesthetics". Proc Soc Exp Biol Med 109: 664–8. PMID 13910333. 

External links

v · d · eAnesthetics: Local anesthetics - primarily sodium channel blockers (N01B)
Esters
Amylocaine • Benzocaine • Butacaine • Butamben • Chloroprocaine • Dimethocaine • Meprylcaine • Metabutoxycaine • Orthocaine • Propoxycaine • Procaine (Novocaine) • Proxymetacaine • Risocaine • Tetracaine
Esters of benzoic acid
3-(p-Fluorobenzoyloxy)tropane • Cocaine • Cyclomethycaine • Hexylcaine • Piperocaine
Amides
Combinations

M: PNS

anat(h/r/t/c/b/l/s/a)/phys(r)/devp/prot/nttr/nttm/ntrp

noco/auto/cong/tumr, sysi/epon, injr

proc, drug(N1B)
v · d · eVasoprotectives (C05)
Antihemorrhoidals for topical use
Antivaricose therapy

heparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate)

sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol)

other (Calcium dobesilate)
Capillary stabilising agents

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)


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