Proxymetacaine

Proxymetacaine

Systematic (IUPAC) name
2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	C(US)
Legal status	?
Routes	Topical (eye drops)
Pharmacokinetic data
Metabolism	Plasma
Identifiers
CAS number	499-67-2 5875-06-9 (HCl)
ATC code	S01HA04
PubChem	CID 4935
DrugBank	APRD00522
ChemSpider	4766 Y
UNII	B4OB0JHI1X Y
KEGG	D08448 Y
ChEMBL	CHEMBL1196 Y
Chemical data
Formula	C16H26N2O3
Mol. mass	294.389 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3 Y Key:KCLANYCVBBTKTO-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Proxymetacaine (INN) or proparacaine (USAN) is a topical anesthetic drug of the aminoester group.

Clinical pharmacology

Indications and usage

Proxymetacaine hydrochloride ophthalmic solution (eye drops) is indicated for procedures such as tonometry, gonioscopy, removal of foreign bodies, or other similar procedures requiring topical anesthesia of the cornea and conjunctiva.

Warnings

Proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection. Prolonged use of this or any other topical ocular anesthetic may produce permanent corneal opacification with accompanying visual loss.

Mechanism of action

Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.

How supplied

Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. Although it is no longer on patent, it is still marketed under the trade names Alcaine, Ak-Taine, and others.

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.v · Categories: Local anesthetics Benzoates Anilines Phenol ethers Nervous system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Obol (coin) Diocese Of Shrewsbury Lourdes Pilgrimage Look at other dictionaries: proxymetacaine hydrochloride — SYN: proparacaine hydrochloride …   Medical dictionary Eye injury — A small piece of iron has lodged near the margin of the cornea Eye injury by impact o …   Wikipedia Cocaine — For other uses, see Cocaine (disambiguation). Cocaine …   Wikipedia Procaine — Novocaine redirects here. For other uses, see Novocaine (disambiguation). Procaine Systematic (IUPAC) name …   Wikipedia Lidocaine — Systematic (IUPAC) name 2 (diethylamino) …   Wikipedia Benzocaine — Systematic (IUPAC) name ethyl p aminobenzoa …   Wikipedia ATC code S01 — A section of the Anatomical Therapeutic Chemical Classification System.S Sensory organs01A Anti infectives01AA Antibiotics:S01AA01 Chloramphenicol:S01AA02 Chlortetracycline:S01AA03 Neomycin:S01AA04 Oxytetracycline:S01AA05 Tyrothricin:S01AA07… …   Wikipedia Bupivacaine — Systematic (IUPAC) name (RS) 1 butyl N (2,6 dimethylphenyl) piperidine 2 carboxamide Clinical data AHFS/ …   Wikipedia Ropivacaine — Systematic (IUPAC) name (S) N (2,6 dimethylphenyl) 1 propylpiperidine 2 carboxamide Clinical data AHFS/Drugs.com …   Wikipedia Tonometry — In music, a tonometer is an instrument used to determine the pitch or vibration rate of tones, such as a tuning fork. Tonometry is the measurement of tension or pressure [http://www.mercksource.org/pp/us/cns/cns hl… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”