Fluocinolone acetonide

Fluocinolone acetonide
Fluocinolone acetonide
Systematic (IUPAC) name
(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat. C
Legal status  ?
Routes Topical
Pharmacokinetic data
Metabolism Hepatic, CYP3A4-mediated
Half-life 1.3 to 1.7 hours
Identifiers
CAS number 67-73-2 YesY
ATC code C05AA10 D07AC04 S01BA15 S02BA08
PubChem CID 6215
DrugBank APRD00977
ChemSpider 5980 YesY
UNII 0CD5FD6S2M YesY
KEGG D01825 YesY
ChEMBL CHEMBL989 YesY
Chemical data
Formula C24H30F2O6 
Mol. mass 452.488 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  acetonide (verify)

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

v · d · eCorticosteroids – glucocorticoids and mineralocorticoids (H02)
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B)
Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE • 11-DEOXYCORTICOSTERONE • HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
Pregnene
Pregnenedione
(+20-one)
Pregnadiene (+1-ene)
Rimexolone • HALOGENATED, WITH FG AT 16: Flunisolide • Triamcinolone • Amcinonide • Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) • HALOGENATED AT 9: Fluorometholone • HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) • Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Pregnatriene
(+2-ene)
HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungrouped
HALOGENATED: Loteprednol • HALOGENATED, WITH FG AT 16: Fludroxycortide • Formocortal • Mometasone furoate
Aldosterone antagonists
Synthesis modifiers

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)
v · d · eVasoprotectives (C05)
Antihemorrhoidals for topical use
Antivaricose therapy

heparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate)

sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol)

other (Calcium dobesilate)
Capillary stabilising agents

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)
v · d · eOtologicals (S02)
Anti-infectives
Corticosteroids
Betamethasone • Dexamethasone • Fluocinolone acetonide • Hydrocortisone • Prednisolone
Analgesics and anesthetics

M: EAR

anat(e/p)/phys/devp

noco/cong, epon

proc, drug(S2)


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