IUPAC_name = 9-fluoro-11,17-dihydroxy-17- (2-hydroxyacetyl)- 10,13-dimethyl- 1,2,6,7,8,9,10,11,12, 13,14,15,16,17- tetradecahydrocyclopenta [a] phenanthren-3-one

CAS_number = 127-31-1
ATC_prefix = H02
ATC_suffix = AA02
ATC_supplemental =
PubChem = 31378
DrugBank = APRD00756
C=21 | H=29 | F=1 | O=5
molecular_weight = 380.45 g/mol
bioavailability =
protein_bound = High
metabolism = Hepatic
elimination_half-life = 3.5 hours
pregnancy_category = C
legal_status =
routes_of_administration = oral

Fludrocortisone is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. It is used primarily to replace the missing hormone aldosterone in various forms of adrenal insufficiency such as Addison's disease and the classic salt wasting (21-hydroxylase deficiency) form of congenital adrenal hyperplasia. It is the first line of treatment for orthostatic intolerance as well.

The brand name in the U.S. is Florinef. It is available in 0.1 mg tablets. Typical daily doses for mineralocorticoid replacement are between 0.05 mg - 0.2 mg. Renin plasma, sodium, and potassium is checked through blood tests in order to verify that the correct dosage is reached.

Chemically, its structure is identical to cortisone except for the substitution of fluorine in place of one hydrogen. Fluorine is a good bioisostere for hydrogen because it is similar in size. The major difference is in its electronegativity.

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Look at other dictionaries:

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  • Fludrocortisone acetate — ФТОРГИДРОКОРТИЗОНА АЦЕТАТ ( Fludrocortisone acetate ). Является фторированным производным гидрокортизона ацетата. Синонимы: Кортинеф, Флоринеф, Alfanonidrone, Cortinef, Florinef, Fludronil и др. По действию сходен с гидрокортизоном. Вызывает… …   Словарь медицинских препаратов

  • fludrocortisone — flu·dro·cor·ti·sone (flo͞o drō kôrʹtĭ sōn , zōn ) n. A synthetic steroid used therapeutically to increase blood pressure by lowering the amount of salt the body excretes.   [Short for fluorohydrocortisone.] * * * …   Universalium

  • fludrocortisone — noun A synthetic corticosteroid hormone normally used, as its acetate, in cases of adrenal insufficiency, or to increase blood pressure …   Wiktionary

  • fludrocortisone — flu·dro·cor·ti·sone .flü drō kȯrt ə .sōn, .zōn n a potent mineralocorticoid drug that is derived from cortisol, possesses some glucocorticoid activity, and is administered in the form of its acetate C23H31FO6 to treat adrenocortical… …   Medical dictionary

  • fludrocortisone — n. a synthetic mineralocorticoid (see corticosteroid) used to treat disorders of the adrenal glands marked by deficient production of aldosterone. It is administered by mouth and side effects include muscle weakness, bone disorders, digestive and …   The new mediacal dictionary

  • fludrocortisone — /ˌfludroʊˈkɔtəzoʊn/ (say .floohdroh kawtuhzohn) noun a type of hydrocortisone containing a fluorine group which has the actions of hydrocortisone but is more potent. {flu(or) 1 + (hy)drocortisone} …  

  • fludrocortisone — A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland …   English dictionary of cancer terms

  • fludrocortisone — …   Useful english dictionary

  • fludrocortisone acetate — A potent mineralocorticoid. SYN: 9α fluorocortisol, 9α fluorohydrocortisone acetate. * * * flu·dro·cor·ti·sone ac·e·tate (floo″dro korґtĭ sōn) [USP] the acetate salt of a synthetic steroid with potent mineralocorticoid and high… …   Medical dictionary

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