Clobetasone

Clobetasone
Clobetasone
Systematic (IUPAC) name
(1R,2S,10S,11S,13S,14R,15S)-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat.  ?
Legal status  ?
Routes topical
Identifiers
CAS number 54063-32-0
ATC code D07AB01 S01BA09
PubChem CID 71387
ChemSpider 64482 YesY
UNII LT69WY1J6D YesY
KEGG D07717 YesY
Synonyms (8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
Chemical data
Formula C22H26ClFO4 
Mol. mass 408.891
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Clobetasone (INN[1]) is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema and other forms of dermatitis, and ophthalmology.

It is available as clobetasone butyrate under the brand name Eumovate[2] or Trimovate,[3] both manufactured by GlaxoSmithKline.

As Trimovate, it also contains Oxytetracycline, an antibiotic, and nystatin, an antifungal[4][5].

References

  1. ^ United Nations Statistics Division - Classifications Registry - Alphabetical index for HS 2002 Entries starting with 'C' (page 310 of 422)
  2. ^ Eumovate cream/ointment, NetDoctor.co.uk
  3. ^ Trimovate cream, NetDoctor.co.uk
  4. ^ 30g Trimovate Cream Box, GSK
  5. ^ Medicines.org.uk - Trimovate info
v · d · eCorticosteroids – glucocorticoids and mineralocorticoids (H02)
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B)
Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE • 11-DEOXYCORTICOSTERONE • HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
Pregnene
Pregnenedione
(+20-one)
Pregnadiene (+1-ene)
Rimexolone • HALOGENATED, WITH FG AT 16: Flunisolide • Triamcinolone • Amcinonide • Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) • HALOGENATED AT 9: Fluorometholone • HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) • Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) • Desonide • HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) • HALOGENATED, WITH FG AT 16: Dexamethasone# • Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) • Beclometasone • Paramethasone  • Alclometasone • Fluclorolone • Flumetasone • Fluprednidene
Pregnatriene
(+2-ene)
HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungrouped
HALOGENATED: Loteprednol • HALOGENATED, WITH FG AT 16: Fludroxycortide • Formocortal • Mometasone furoate
Aldosterone antagonists
Synthesis modifiers

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)


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