Alclometasone

drugbox
IUPAC_name = [7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta [a] phenanthren-17-yl] propanoate

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CAS_number = 66734-13-2
ATC_prefix = D07
ATC_suffix = AB10
ATC_supplemental = ATC|S01|BA10
PubChem = 636374
DrugBank = APRD00783
C=28 | H=37 | Cl=1 | O=7
molecular_weight = 521.042 g/mol
bioavailability =
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routes_of_administration = topical

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and onintment are indicated forthe relief of corticosteroid-responsive dermatoses, including:

atopic dermatitis

eczema

psoriasis

allergic dermatitis

contact dermatitis

actinic dermatitis

kiss-type allergy

skin itch
Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year orolder and in geriatric patients.

Contraindications

hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms

cutaneous tuberculosis

chicken pox

perioral dermatitis

acne

rosacea

open wounds

trophic ulcers

viral infection of skin

skin manifestations of syphilis

ide effects

Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:

burning

itching

erythema

skin reddening

xerodermia

skin irritation

acne

hypopigmentation

prickly heat

folliculitis

white atrophy

hypertrichosis

reinfection of skin

How supplied

Alclometasone as Aclovate is supplied in:

Cream; Topical; 0.05%

Ointment; Topical; 0.05%

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