Diflorasone

Diflorasone
Diflorasone
Systematic (IUPAC) name
[17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate
Clinical data
Trade names Psorcon
AHFS/Drugs.com monograph
MedlinePlus a602019
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 1-13-8 N
ATC code D07AC10
PubChem CID 71414
DrugBank APRD00921
ChemSpider 64504 YesY
UNII T2DHJ9645W YesY
KEGG D01327 YesY
ChEBI CHEBI:31483 YesY
ChEMBL CHEMBL1201380 N
Chemical data
Formula C26H32F2O7 
Mol. mass 494.525 g/mol
 N(what is this?)  (verify)

Diflorasone is a corticosteroid that comes in the form of a cream containing diflorasone diacetate. In is manufactured by E. Fougera & Co. and is used for its anti-inflammatory and anti-itching qualities, like other topical corticosteroids. It is often prescribed for psoriasis and atopic dermatitis, and also for Hailey–Hailey disease. It is considered to be of greater potency compared to other topical corticosteroids.[citation needed]

No long-term animal studies have been done to determine whether diflorasone could have carcinogenic properties.

Women who are breastfeeding their newborns should probably not use diflorasone since corticosteroids have been known to appear in breast milk and cause negative effects in a newborn,[citation needed] such as inhibited growth, but little data is available regarding whether topical corticosteroids like diflorasone would be present in great enough quantities to cause harm to an infant.

v · d · eCorticosteroids – glucocorticoids and mineralocorticoids (H02)
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B)
Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Pregnenedione: ALDOSTERONE • 11-DEOXYCORTICOSTERONE • HALOGENATED AT 9: Fludrocortisone
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
Pregnene
Pregnenedione
(+20-one)
Pregnadiene (+1-ene)
Rimexolone • HALOGENATED, WITH FG AT 16: Flunisolide • Triamcinolone • Amcinonide • Fluocinolone acetonide (Fluocinonide)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) • HALOGENATED AT 9: Fluorometholone • HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) • Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Prednisolone# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) • Desonide • HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) • HALOGENATED, WITH FG AT 16: Dexamethasone# • Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) • Beclometasone • Paramethasone  • Alclometasone • Fluclorolone • Flumetasone • Fluprednidene
Pregnatriene
(+2-ene)
HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungrouped
HALOGENATED: Loteprednol • HALOGENATED, WITH FG AT 16: Fludroxycortide • Formocortal • Mometasone furoate
Aldosterone antagonists
Synthesis modifiers

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)


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