Aldosterone antagonist

Aldosterone antagonist

Aldosterone antagonist refers to drugs which antagonise the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure. Spironolactone, the first member of the class, is also used in the management of hyperaldosteronism (including Conn's syndrome) and female hirsutism.

Mode of action

Aldosterone antagonists are, as the name suggests, receptor antagonists at the mineralocorticoid receptor. Antagonism of these receptors inhibits sodium resorption in the collecting duct of the nephron in the kidneys. This interferes with sodium/potassium exchange, reducing urinary potassium excretion and weakly increasing water excretion (diuresis). [Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006.]

Their adjunctive use in congestive heart failure relates to their additive diuretic effect in combination with other drugs, reducing edema and decreasing the cardiac workload.

Examples

Members of this class in clinical use include:
* Spironolactone
* Eplerenone
* Canrenone

ee also

* Potassium-sparing diuretic
* ATC code C03#C03DA Aldosterone antagonists

References

External links

*
*


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • aldosterone antagonist — any of a group of compounds that block the action of aldosterone and function as potassium sparing diuretics; they compete with aldosterone for receptor sites, thus blocking the aldosterone dependent exchange of sodium and potassium in the distal …   Medical dictionary

  • Aldosterone — Chembox new ImageFile = Aldosterone 2D skeletal.svg ImageSize = IUPACName = 11β,21 dihydroxy 3,20 dioxopregn 4 en 18 al OtherNames = Section1 = Chembox Identifiers CASNo = 52 39 1 PubChem = 5839 SMILES = C [C@] 12CCC(=O)C=C1CC [C@@H] 3 [C@@H] 2… …   Wikipedia

  • Antagonist — In biochemistry, an antagonist acts against and blocks an action. For example, insulin lowers the level of glucose (sugar) in the blood, whereas another hormone called glucagon raises it; therefore, insulin and glucagon are antagonists. An… …   Medical dictionary

  • Système rénine-angiotensine-aldostérone — Schéma du système rénine angiotensine aldostérone dans sa complexité …   Wikipédia en Français

  • Cholecystokinin antagonist — A Cholecystokinin antagonist is a specific type of receptor antagonist which blocks the receptor sites for the peptide hormone Cholecystokinin (CCK). There are two subtypes of this receptor known at present, defined as CCKA and CCKB (also called… …   Wikipedia

  • Angiotensin II receptor antagonist — Angiotensin II receptor antagonists, also known as angiotensin receptor blockers (ARBs), AT1 receptor antagonists or sartans, are a group of pharmaceuticals which modulate the renin angiotensin aldosterone system. Their main use is in… …   Wikipedia

  • Corticotropin releasing hormone antagonist — A Corticotropin releasing hormone antagonist is a specific type of receptor antagonist which blocks the receptor sites for Corticotropin releasing hormone (also known as Corticotropin releasing factor (CRF)), blocking therefore the consequent… …   Wikipedia

  • angiotensin receptor antagonist — angiotensin II receptor antagonist any of a class of antihypertensive agents that block the vasoconstrictor and aldosterone secreting effects of angiotensin II by competitive binding with angiotensin receptors. Called also angiotensin receptor or …   Medical dictionary

  • spironolactone — Aldosterone antagonist: diuretic; used to treat low renin hypertension, and Conn s syndrome (in which there is overproduction of aldesterone) …   Dictionary of molecular biology

  • Spironolactone — Systematic (IUPAC) name 7α Acetylthio 3 oxo 17α pregn 4 ene 21,17 carbolactone OR (1 S,2R,2 R,9 R,10 R,11 S,15 S) 9 (acetylsulfanyl) 2 ,15 dimethylspiro[oxolane 2,14 tetracyclo[8.7.0.0 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”