Phenazone

Drugbox
IUPAC_name = 1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one

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CAS_number=60-80-0
ATC_prefix=N02
ATC_suffix=BB01
ATC_supplemental=
PubChem=2206
DrugBank= DB01435
ChemSpiderID=2121
C=11 | H=12 | N=2 | O=1
molecular_weight = 188.226
bioavailability=
metabolism =
elimination_half-life=
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smiles = CN(C(C)=CC2=O) N2C1=CC=CC=C1

Phenazone, or phenazon, is an analgesic. It was first synthesised by Ludwig Knorr in 1883. It is formed by reducing diortho-dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 C. It crystallizes in needles which melt at 156 C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid.

ynonyms

Analgesine, Antipyrine, Diméthyloxyquinazine, Oxydiméthylquinazine, Oxydiméthylquinizine, Pyrazoline

ee also

Propyphenazone

Chimic Class

* Pyrazole
* Pyrazolinone

Pharmacology

* Analgesics
* Antipyretic
* NSAID

Adverse effects

* Allergy to pyrazolones
* Nausea
* Agranulocytosis
* hepatotoxic