Beta2-adrenergic agonist

Beta2-adrenergic agonist

Beta2-adrenergic agonists, also known as Beta2-adrenergic receptor agonists, are a class of drugs used to treat asthma and other pulmonary disease states.


They act on the Beta-2 adrenergic receptor, thereby causing smooth muscle relaxation resulting in dilation of bronchial passages, vasodilation in muscle and liver, relaxation of uterine muscle and release of insulin. Side effects such as insomnia, anxiety, and tremor occur in some patients. All β2 agonists are available in inhaler form (either metered-dose inhalers, which aerosolize the drug, or dry powder which can be inhaled).

Salbutamol (known as albuterol in the U.S.) also comes in a solution form for nebulization, which is more commonly used in emergency rooms than inhalers. Salbutamol and terbutaline are also both available in oral forms.

In addition, several of these medications are available in intravenous forms including both salbutamol and terbutaline. It can be used in this form in severe cases of asthma, but more commonly it is used to suppress premature labor because it also relaxes uterine muscle, thereby inhibiting contractions.


On November 18, 2005, Food and Drug Administration (FDA) alerted health care professionals and patients that several long-acting bronchodilator medicines have been associated with possible increased risk of worsening wheezing (bronchospasm) in some people, and requested that manufacturers update warnings in their existing product labeling.

On June 29, 2006, Cornell University and Stanford University researchers reported that a meta-analysis they conducted found that "regularly inhaled beta-agonists (Orciprenaline/metaproterenol [Alupent] , formoterol [Foradil] , Fluticasone/salmeterol [Serevent, Advair] and Salbutamol/albuterol [Proventil, Ventolin, Volmax and others] ) increased the risk of respiratory death more than twofold, compared with a placebo," while used to treat chronic obstructive pulmonary disease (COPD). [Ramanujan K. Common beta-agonist inhalers more than double death rate in COPD patients, Cornell and Stanford scientists assert. "Chronicle Online". June 29, 2006. Available at: Accessed June 30, 2006.]


They can be divided into short-acting and long acting beta-adrenoceptor agonist (LABA) groups:

hort-acting beta2 agonists

*salbutamol (Albuterol, Ventolin)
*bitolterol mesylate

Long-acting beta2 agonists


Ultra long-acting beta2 agonists



External links


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Beta adrenergic receptor kinase-2 — Adrenergic, beta, receptor kinase 2, also known as ADRBK2, is a human gene. PBB Summary section title = summary text = The beta adrenergic receptor kinase specifically phosphorylates the agonist occupied form of the beta adrenergic and related G… …   Wikipedia

  • Beta-2 adrenergic receptor — The beta 2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is an beta adrenergic receptor, and also denotes the human gene encoding it.cite web | title = Entrez Gene: ADRB1 adrenergic, beta 1 , receptor| url =… …   Wikipedia

  • Beta-1 adrenergic receptor — The beta 1 adrenergic receptor (β1 adrenoreceptor), also known as ADRB1, is an beta adrenergic receptor, and also denotes the human gene encoding it.ReceptorActionsActions of the β1 receptor include: *stimulate viscous, amylase filled secretions… …   Wikipedia

  • Dyspnea — ICD 10 R06.0 ICD 9 786.09 DiseasesDB 15892 …   Wikipedia

  • List of doping cases in sport — Part of a series on Doping in sport …   Wikipedia

  • Whizzinator — Part of a series on Doping in sport …   Wikipedia

  • Doping at the Tour de France — Spectators banner during the Tour de France 2006 Part of a s …   Wikipedia

  • Operación Puerto doping case — Part of a series on Doping in sport …   Wikipedia

  • Performance-enhancing drugs — Part of a series on Doping in sport …   Wikipedia

  • Doping at the 2007 Tour de France — Part of a series on Doping in sport …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”