Nedocromil

Nedocromil

Systematic (IUPAC) name
9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Clinical data
Trade names	Alocril
AHFS/Drugs.com	monograph
MedlinePlus	a601243
Pregnancy cat.	?
Legal status	POM (UK) ℞-only (US)
Routes	Inhalation and eye drops
Pharmacokinetic data
Protein binding	89%
Metabolism	not metabolized
Half-life	~3.3 hours
Excretion	excreted unchanged
Identifiers
CAS number	69049-73-6 Y
ATC code	R01AC07 R03BC03, S01GX04
PubChem	CID 50294
DrugBank	APRD01137
ChemSpider	45608 Y
UNII	0B535E0BN0 Y
KEGG	D05129 Y
ChEBI	CHEBI:7492 N
ChEMBL	CHEMBL746 Y
Chemical data
Formula	C19H17NO7
Mol. mass	371.341 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26) Y Key:RQTOOFIXOKYGAN-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade (although its effects in this form are far less than those in albuterol or other well known inhaler medications) and as an eye drop under the brand name Alocril. Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.^[1]

Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.^[2]

References

1. ^ "Nedocromil eye drops" (in English). 2007-02-02. http://www.patient.co.uk/showdoc/30003772. Retrieved 2009-08-04. 
2. ^ http://www.fda.gov/downloads/Drugs/DrugSafety/DrugShortages/ucm089433.pdf

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.v · Categories: Mast cell stabilizers Ophthalmology drugs Dicarboxylic acids Quinolones Chromones Respiratory system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Monument Park (Yankee Stadium) List of Statutory Instruments of Scotland, 2001 Look at other dictionaries: nedocromil — fármaco emparentado con el cromoglicato, utilizado en el tratamiento del asma alérgico estructura química [véase http://www.iqb.es/diccio/n/ne.htm#nedocromil] Diccionario ilustrado de Términos Médicos.. Alvaro Galiano. 2010 …   Diccionario médico Nedocromil — Strukturformel Allgemeines Freiname Nedocromil …   Deutsch Wikipedia nedocromil — Eng. Nedocromil Estabilizador de la membrana de los mastocitos útil en la profilaxis de procesos alérgicos a nivel ocular cuando se administra por vía tópica …   Diccionario de oftalmología nedocromil sodium — ne·do·cro·mil sodium nə däk rə mil, .ned ə krō n an anti inflammatory disodium salt C19H15NNa2O7 that is administered either as an aerosol by oral inhalation for the treatment of mild to moderate asthma or as eyedrops for the treatment of itching …   Medical dictionary nedocromil — noun A medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma …   Wiktionary nedocromil — n. a drug used to prevent asthma attacks and to treat allergic conjunctivitis. It is administered by metered dose aerosol inhaler or as eye drops; possible side effects include local irritation. Trade names: Rapitil, Tilade. * * * ned·o·cro·mil… …   Medical dictionary nedocromil — n. a drug, related to sodium cromoglicate, used to prevent asthma attacks and to treat allergic conjunctivitis. It is administered by metered dose aerosol inhaler or as eye drops; possible side effects include local irritation. Trade names:… …   The new mediacal dictionary Nedocromil sodium — НЕДОКРОМИЛ НАТРИЙ ( Nеdоcromil sodium )* 9 Этил 6,9 дигидро 4,6 диоксо 10 пропил 4Н пирано[3,2 g] хинолин 2,8 дикарбоновой кислоты динатриевая соль. Синонимы: Тайлед, Тiladе. По химической структуре имеет элементы сходства с кромолин натрием и… …   Словарь медицинских препаратов Недокромил (Nedocromil) — противовоспалительное лекарственное вещество, применяемое для лечения бронхита и бронхиальной астмы. Назначается в аэрозольных ингаляциях в строго фиксированных дозах; возможные побочные эффекты: тошнота и быстро проходящая головная боль.… …   Медицинские термины НЕДОКРОМИЛ — (nedocromil) противовоспалительное лекарственное вещество, применяемое для лечения бронхита и бронхиальной астмы. Назначается в аэрозольных ингаляциях в строго фиксированных дозах; возможные побочные эффекты: тошнота и быстро проходящая головная… …   Толковый словарь по медицине 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”