Doxofylline

Doxofylline
Doxofylline
Systematic (IUPAC) name
7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status ℞ Prescription only
Routes Oral
Identifiers
CAS number 69975-86-6
ATC code R03DA11
PubChem CID 50942
UNII MPM23GMO7Z YesY
KEGG D03898 YesY
Chemical data
Formula C11H14N4O4 
Mol. mass 266.25 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Doxofylline (INN), (also known as doxophylline) is a xanthine derivative drug used in the treatment of asthma.[1]

It has antitussive[citation needed] and bronchodilator[2] effects, and acts as a phosphodiesterase inhibitor.[3]

In animal and human studies, it has shown similar efficacy to theophylline but with significantly less side effects.[4]

Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects. This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions on phosphodiesterase.[1]

References

  1. ^ a b Cirillo R, Barone D, Franzone JS (1988). "Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors". Arch Int Pharmacodyn Ther 295: 221–37. PMID 3245738. 
  2. ^ Poggi R, Brandolese R, Bernasconi M, Manzin E, Rossi A (October 1989). "Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure". Chest 96 (4): 772–8. doi:10.1378/chest.96.4.772. PMID 2791671. http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=2791671. 
  3. ^ Dini FL, Cogo R (2001). "Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects". Curr Med Res Opin 16 (4): 258–68. doi:10.1185/030079901750120196. PMID 11268710. 
  4. ^ Sankar J, Lodha R, Kabra SK (March 2008). "Doxofylline: The next generation methylxanthine". Indian J Pediatr 75 (3): 251–4. doi:10.1007/s12098-008-0054-1. PMID 18376093. 

5. Dali Shukla, Subhashis Chakraborty, Sanjay Singh & Brahmeshwar Mishra. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy. 2009; 10(14): 2343-2356, DOI 10.1517/14656560903200667, PMID: 19678793

v · d · eDrugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants
other
Glucocorticoids
Anticholinergics/
muscarinic antagonist
Ipratropium bromide# • Oxitropium bromide • Tiotropium bromide
Mast cell stabilizers
Cromoglicate • Nedocromil
Xanthines
Eicosanoid inhibition
Thromboxane receptor antagonists
Combination products
#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III

M: RES

anat(n, x, l, c)/phys/devp

noco(c, p)/cong/tumr, sysi/epon, injr

proc, drug(R1/2/3/5/6/7)
v · d · ePhosphodiesterase inhibitors
PDE1
MMPX • SCH-51866 • Vinpocetine
PDE2
BAY 60-7550 • EHNA
PDE3
Amrinone • Anagrelide • Bucladesine • Cilostamide • Cilostazol • Enoximone • KMUP-1 • Milrinone • Quazinone • RPL-554 • Siguazodan • Trequinsin • Vesnarinone • Zardaverine
PDE4
Arofylline • Cilomilast • CP-80633 • Denbutylline • Drotaverine • Etazolate • Filaminast • Glaucine • HT-0712 • Ibudilast • ICI-63197 • Irsogladine • Luteolin • Mesembrine • Roflumilast • Rolipram • Ro20-1724 • RPL-554 • YM-976
PDE5
Acetildenafil • Aildenafil • Avanafil • Dipyridamole • Icariin • Lodenafil • Mirodenafil • MY-5445 • Sildenafil • Sulfoaildenafil • T-0156 • Tadalafil • Udenafil • Vardenafil
PDE6
Zaprinast
PDE7
BRL-50481
PDE9
BAY 73-6691 • SCH-51866
PDE10
Nonselective
Caffeine • Doxofylline • IBMX • Pentoxifylline • Propentofylline • Theophylline


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