Aildenafil

Aildenafil
IUPAC name 5-(5-(((3R,5S)-3,5-Dimethylpiperazin-1-yl)sulfonyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(4H)-one
Other names Methisosildenafil
Identifiers
CAS number	496835-35-9
PubChem	16721107
ChemSpider	8316620 Y
Jmol-3D images	Image 1
SMILES O=S(=O)(c3cc(C\1=N\C(=O)c2c(N/1)c(nn2C)CCC)c(OCC)cc3)N4C[C@H](N[C@@H](C)C4)C
InChI InChI=1S/C23H32N6O4S/c1-6-8-18-20-21(28(5)27-18)23(30)26-22(25-20)17-11-16(9-10-19(17)33-7-2)34(31,32)29-12-14(3)24-15(4)13-29/h9-11,14-15,24H,6-8,12-13H2,1-5H3,(H,25,26,30)/t14-,15+ Y Key: NFSWSZIPXJAYLR-GASCZTMLSA-N Y
Properties
Molecular formula	C23H32N6O4S
Molar mass	488.6 g mol−1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Aildenafil (methisosildenafil) is a synthetic chemical compound that is a structural analog of sildenafil (Viagra).^[1] It was first reported in 2003,^[2] and it is not approved by any health regulation agency. Like sildenafil, aildenafil is a phosphodiesterase type 5 inhibitor.

Aildenafil has been found as an adulterant in a variety of supplements which are sold as "natural" or "herbal" sexual enhancement products.^{[3][4][5][6][7]} The United States Food and Drug Administration has warned consumers that any sexual enhancement product that claims to work as well as prescription products is likely to contain such a contaminant.^[8]

See also

• Sulfoaildenafil

References

1. ^ Zhao, Xia; Sun, Peihong; Zhou, Ying; Liu, Yuwang; Zhang, Huilin; Gu, Jingkai; Cui, Yimin (2009). "Pharmacokinetics and safety of aildenafil tablets in healthy Chinese male subjects after multiple dose administration". Zhongguo Linchuang Yaolixue Zazhi 25 (2): 120–123. 
2. ^ Liu, Baoshun. Preparation of pyrazolopyrimidine derivatives for treatment of impotence. WO 2003016313 
3. ^ Gryniewicz, CM; Reepmeyer, JC; Kauffman, JF; Buhse, LF (2009). "Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry". Journal of pharmaceutical and biomedical analysis 49 (3): 601–6. doi:10.1016/j.jpba.2008.12.002. PMID 19150190. 
4. ^ Choi, Dong Mi; Park, Sangaeh; Yoon, Tae Hyung; Jeong, Hye Kyoung; Pyo, Jae Sung; Park, Janghyun; Kim, Deukjoon; Kwon, Sung Won (2008). "Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry". Journal of AOAC International 91 (3): 580–588. PMID 18567304. 
5. ^ Reepmeyer, John C.; Woodruff, Jeffrey T. (2007). "Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement". Journal of Pharmaceutical and Biomedical Analysis 44 (4): 887–893. doi:10.1016/j.jpba.2007.04.011. PMID 17532168. 
6. ^ Reepmeyer, John C.; Woodruff, Jeffrey T.; 'Avignon, D. Andre. (2007). "Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement". Journal of Pharmaceutical and Biomedical Analysis 43 (5): 1615–1621. doi:10.1016/j.jpba.2006.11.037. PMID 17207601. 
7. ^ Enforcement Report for June 30, 2010, United States Food and Drug Administration
8. ^ Hidden Risks of Erectile Dysfunction "Treatments" Sold Online, United States Food and Drug Administration, February 21, 2009