drugbox
IUPAC_name = 3-methyl-1-(5-oxohexyl)-7-propylpurine-2,6-dione
CAS_number = 55242-55-2
ATC_prefix = N06
ATC_suffix = BC02
PubChem = 4938
DrugBank =
C = 15 | H = 22 | N = 4 | O = 3
molecular_weight = 306.360 g/mol
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Propentofylline is a xanthine derivative with purported neuroprotective effects.
Pharmacology
It is a phosphodiesterase inhibitor.
It also inhibits adenosine uptake.[cite journal |author=Frampton M, Harvey RJ, Kirchner V |title=Propentofylline for dementia |journal=Cochrane Database Syst Rev |volume= |issue=2 |pages=CD002853 |year=2003 |pmid=12804440 |doi=10.1002/14651858.CD002853 |url=http://dx.doi.org/10.1002/14651858.CD002853] ]Uses
It is being studied as a possible treatment for Alzheimer's disease and multi-infarct dementia. [cite journal |author=Frampton M, Harvey RJ, Kirchner V |title=Propentofylline for dementia |journal=Cochrane database of systematic reviews (Online) |volume= |issue=2 |pages=CD002853 |year=2003 |pmid=12804440 |doi=10.1002/14651858.CD002853] [cite journal |author=Kittner B, Rössner M, Rother M |title=Clinical trials in dementia with propentofylline |journal=Ann. N. Y. Acad. Sci. |volume=826 |issue= |pages=307–16 |year=1997 |pmid=9329701 |doi=]
Propentofylline has also been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties. [cite journal |author=Bath PM, Bath-Hextall FJ |title=Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke |journal=Cochrane database of systematic reviews (Online) |volume= |issue=3 |pages=CD000162 |year=2004 |pmid=15266424 |doi=10.1002/14651858.CD000162.pub2] [cite journal |author=Huber M, Kittner B, Hojer C, Fink GR, Neveling M, Heiss WD |title=Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke |journal=J. Cereb. Blood Flow Metab. |volume=13 |issue=3 |pages=526–30 |year=1993 |pmid=8478410 |doi=]
ee also
*Pentoxifylline
References
