Enoximone

Enoximone

drugbox
IUPAC_name = 4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-
dihydroimidazol-2-one



CAS_number = 77671-31-9
ATC_prefix = C01
ATC_suffix = CE03
PubChem = 53708
DrugBank =
smiles = CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2
C = 12 | H = 12 | N = 2 | O = 2 | S = 1
molecular_weight = 248.302 g/mol
bioavailability = 50% (oral)
protein_bound = 85%
metabolism = Hepatic oxidation
elimination_half-life = 4 to 10 hours
excretion = Renal (60 to 70%)
pregnancy_AU =
pregnancy_US =
pregnancy_category =
legal_AU =
legal_UK = POM
legal_US =
legal_status =
routes_of_administration = Intravenous

Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure. Selective for phosphodiesterase 3


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  • enoximone — n. an inotropic drug used in heart failure to increase the force and output of the heart. It is administered by injection. Trade name: Perfan. * * * enox·i·mone (ə nokґsĭ mōn) a phosphodiesterase inhibitor similar to inamrinone,… …   Medical dictionary

  • enoximone — n. an inotropic drug used in heart failure to increase the force and output of the heart. It is administered by injection. Trade names: Perfan …   The new mediacal dictionary

  • Эноксимон (Enoximone) — инотропное лекарственное вещество, применяемое при сердечной недостаточности для увеличения силы сердечных сокращений и выброса крови из сердца. Назначается в инъекциях. Торговое название: перфан (Perfan). Источник: Медицинский словарь …   Медицинские термины

  • ЭНОКСИМОН — (enoximone) инотропное лекарственное вещество, применяемое при сердечной недостаточности для увеличения силы сердечных сокращений и выброса крови из сердца. Назначается в инъекциях. Торговое название: перфан (Perfan) …   Толковый словарь по медицине

  • PDE3 inhibitor — Milrinone, one of the first PDE3 inhibitors used clinically A PDE3 inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic shock. Approved PDE3… …   Wikipedia

  • Phosphodiesterase inhibitor — A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and… …   Wikipedia

  • Milrinone — Systematic (IUPAC) name 2 methyl 6 oxo 1,6 dihydro 3,4 bipyridine 5 carbonitrile Clinical data AHFS/Drugs.com …   Wikipedia

  • Amrinone — Systematic (IUPAC) name 5 amino 3,4 bipyridin 6(1H) one Clinical data AHFS/Drugs.com …   Wikipedia

  • Bucladesine — Systematic (IUPAC) name sodium (3aR,4R,6R,6aR) 4 (6 butanamido 9H purin 9 yl) 6 [(butanoyloxy)methyl] 2 oxo tetrahydro 2H 1,3,5,2λ5 furo[3,4 d][1,3,2]dioxaphosphol 2 olate …   Wikipedia

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