Mirodenafil

Mirodenafil
Mirodenafil
Systematic (IUPAC) name
5-Ethyl-3,5-dihydro-2-[5-([4-(2-hydroxyethyl)-1-piperazinyl]sulfonyl)-2-propoxyphenyl]-7-propyl-4H-pyrrolo[3,2-d]pyrimidin-4-one
Clinical data
Pregnancy cat.  ?
Legal status Unscheduled
Identifiers
CAS number 862189-95-5
ATC code  ?
PubChem CID 12001014
UNII 504G362H0H YesY
Chemical data
Formula C26H37N5O5S 
Mol. mass 531.666 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Mirodenafil is an experimental drug belonging to a class of drugs called PDE5 inhibitors, which many other erectile dysfunction drugs such as sildenafil, tadalafil, and vardenafil also belong to. Like udenafil, lodenafil and avanafil it belongs to a new generation of PDE5 inhibitors.

It is not currently approved for use in the United States by the U.S. Food and Drug Administration, but clinical trials are being conducted.[1][2][3]

References

  1. ^ Paick JS, Ahn TY, Choi HK, Chung WS, Kim JJ, Kim SC, Kim SW, Lee SW, Min KS, Moon KH, Park JK, Park K, Park NC, Suh JK, Yang DY, Jung HG (November 2008). "Efficacy and safety of mirodenafil, a new oral phosphodiesterase type 5 inhibitor, for treatment of erectile dysfunction". The Journal of Sexual Medicine 5 (11): 2672–80. doi:10.1111/j.1743-6109.2008.00945.x. PMID 18638004. 
  2. ^ Kim BH, Yi S, Kim J, Lim KS, Kim KP, Lee B, Shin SG, Jang IJ, Yu KS (June 2009). "Influence of alcohol on the hemodynamic effects and pharmacokinetic properties of mirodenafil: a single-dose, randomized-sequence, open-label, crossover study in healthy male volunteers in Korea". Clinical Therapeutics 31 (6): 1234–43. doi:10.1016/j.clinthera.2009.06.008. PMID 19695390. 
  3. ^ Shin KH, Kim BH, Kim TE, Kim JW, Yi S, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS (December 2009). "The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study". Clinical Therapeutics 31 (12): 3009–20. doi:10.1016/j.clinthera.2009.12.012. PMID 20110038. 



v · d · eUrologicals, including antispasmodics (G04B)
Acidifiers
Urinary antispasmodics
(primarily antimuscarinics)
Darifenacin • Emepronium • Fesoterodine • Flavoxate • Imidafenacin • Meladrazine • Oxybutynin • Propiverine • Solifenacin • Terodiline • Tolterodine • Trospium chloride
Other urologicals

M: URI

anat/phys/devp/cell

noco/acba/cong/tumr, sysi/epon, urte

proc/itvp, drug (G4B), blte, urte
v · d · ePhosphodiesterase inhibitors
PDE1
MMPX • SCH-51866 • Vinpocetine
PDE2
BAY 60-7550 • EHNA
PDE3
Amrinone • Anagrelide • Bucladesine • Cilostamide • Cilostazol • Enoximone • KMUP-1 • Milrinone • Quazinone • RPL-554 • Siguazodan • Trequinsin • Vesnarinone • Zardaverine
PDE4
Arofylline • Cilomilast • CP-80633 • Denbutylline • Drotaverine • Etazolate • Filaminast • Glaucine • HT-0712 • Ibudilast • ICI-63197 • Irsogladine • Luteolin • Mesembrine • Roflumilast • Rolipram • Ro20-1724 • RPL-554 • YM-976
PDE5
Acetildenafil • Aildenafil • Avanafil • Dipyridamole • Icariin • Lodenafil • Mirodenafil • MY-5445 • Sildenafil • Sulfoaildenafil • T-0156 • Tadalafil • Udenafil • Vardenafil
PDE6
Zaprinast
PDE7
BRL-50481
PDE9
BAY 73-6691 • SCH-51866
PDE10
Nonselective


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