Orciprenaline

Orciprenaline

Systematic (IUPAC) name
(RS)-5-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,3-diol
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682084
Pregnancy cat.	A(AU) C(US)
Legal status	℞-only (US)
Routes	Inhalation / tablets
Pharmacokinetic data
Bioavailability	3% if inhaled, 40% if taken orally
Metabolism	Gastrointestinal and hepatic
Half-life	6 hours
Identifiers
CAS number	586-06-1 Y
ATC code	R03AB03 R03CB03 R03CB53
PubChem	CID 4086
DrugBank	DB00816
ChemSpider	3944 Y
UNII	53QOG569E0 Y
KEGG	D08300 Y
ChEMBL	CHEMBL776 Y
Chemical data
Formula	C11H17NO3
Mol. mass	211.258 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8/h3-5,7,11-15H,6H2,1-2H3 Y Key:LMOINURANNBYCM-UHFFFAOYSA-N Y
Physical data
Solubility in water	9.7 mg/mL (20 °C)
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Orciprenaline (INN, also known as metaproterenol) is a bronchodilator used in the treatment of asthma. Orciprenaline is a moderately selective beta₂-adrenergic receptor agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. The pharmacologic effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of ATP to cAMP. Increased cAMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from many cells, especially from mast cells.

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.v · Categories: Phenethylamines Respiratory system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Heterogynidae Herald News Look at other dictionaries: orciprenaline — n. a sympathomimetic drug used as a bronchodilator to relieve bronchitis and asthma. It is administered by mouth; side effects include dizziness and tremor. Trade name: Alupent …   Medical dictionary orciprenaline — …   Useful english dictionary orciprenaline sulfate — SYN: metaproterenol sulfate …   Medical dictionary Орципреналин (Orciprenaline) — лекарственное вещество; применяется для лечения бронхита и астмы. Обладает таким же действием и имеет те же побочные эффекты, что и изопреналин. Торговое название: алупент (Alupent). Источник: Медицинский словарь …   Медицинские термины ОРЦИПРЕНАЛИН — (orciprenaline) лекарственное вещество; применяется для лечения бронхита и астмы. Обладает таким же действием и имеет те же побочные эффекты, что и изопреналин. Торговое название: алупент (Alupent) …   Толковый словарь по медицине Methylbenzodioxolylpentanamine — IUPAC name 1 (1,3 benzodioxol 5 yl) N methylpentan 2 amine …   Wikipedia Ethylbenzodioxolylpentanamine — IUPAC name 1 (1,3 benzodioxol 5 yl) N ethylpentan 2 amine …   Wikipedia Methylenedioxyhydroxyamphetamine — Systematic (IUPAC) name %28%C2%B1%29 1 %28benzo[d][1%2C3]dioxol 5 yl%29 N hydroxylpropan 2 amine Clinical data Trade names …   Wikipedia Methylenedioxyhydroxymethamphetamine — Systematic (IUPAC) name (±) 1 (benzo[d][1,3]dioxol 5 yl) N hydroxyl N methylpropan 2 amine Clinical data Pregnancy cat …   Wikipedia Ethylbenzodioxolylbutanamine — IUPAC name (1 Benzo[1,3]dioxol 5 ylmethyl propyl) ethyl amine …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”