Terbutaline

Terbutaline

drugbox
IUPAC_name = 5-(1-hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol


CAS_number = 23031-25-6
ATC_prefix = R03
ATC_suffix = AC03
ATC_supplemental = ATC|R03|CC03
PubChem = 5403
DrugBank = APRD00589
C=12 | H=19 | N=1 | O=3
molecular_weight = 225.284 g/mol
bioavailability =
protein_bound =
metabolism = GI tract (oral), liver; CYP450: unknown
elimination_half-life = urine 90% (60% unchanged), bile/faeces; Half-life: 3-4h
pregnancy_category = B
legal_AU =
legal_CA =
legal_UK = POM
legal_US =
legal_status =
routes_of_administration = SQ, Oral, Inhaled

Terbutaline (trade names "Brethine", "Bricanyl", or "Brethaire") is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour. The inhaled form of terbutaline starts working within 15 minutes and can last up to 6 hours.

Terbutaline as a treatment for premature labour is an off-label use not approved by the FDA. It is a pregnancy category 'B' medication and is routinely prescribed to stop contractions. Terbutaline is currently on the World Anti-Doping Agency's list of prohibited drugs, except, when administered by inhalation, a Therapeutic Use Exemption (TUE) has been obtained in advance.

ide effects

*Maternal - tachycardia, nervousness, tremors, headache, hyperglycemia, hypokalemia, and rarely, pulmonary edema.Cite book | author=Shen, Howard | title=Illustrated Pharmacology Memory Cards: PharMnemonics | date=2008 | publisher=Minireview | isbn=1-59541-101-1 | pages=7]
*Fetal - tachycardia and hypoglycemiaFact|date=August 2008.

Terbutaline is preferred over Ritodrine because it has minimal effects on blood pressure.Fact|date=August 2008.

References


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Look at other dictionaries:

  • Terbutaline — Structure chimique de la terbutaline Général Nom IUPAC 5 [2 [(1,1 Diméthylenthyl)amino] 1 hydroxyéthyl] 1,3 benzènediol …   Wikipédia en Français

  • terbutaline — noun Etymology: tert tertiary + butaline, perhaps by shortening & alteration from butyl + amino + 2 ine Date: 1973 a bronchodilator C12H19NO3 used especially in the form of its sulfate …   New Collegiate Dictionary

  • terbutaline — /teuhr byooht l een /, n. Pharm. a selective beta adrenergic receptor agonist substance, C12H19NO3, used in the treatment of asthma. [TER + BUT(YL) + AL3 + INE2] * * * …   Universalium

  • terbutaline — noun A β2 adrenergic receptor agonist, used as a fast acting bronchodilator and as a tocolytic to delay premature labour …   Wiktionary

  • terbutaline — ter·bu·ta·line tər byüt ə .lēn n a bronchodilator used esp. in the form of its sulfate (C12H19NO3)2·H2SO4 * * * n. a bronchodilator drug (see sympathomimetic) used in the treatment of asthma, bronchitis, and other respiratory disorders. It may be …   Medical dictionary

  • terbutaline — [tə: bju:təli:n] noun Medicine a synthetic compound with bronchodilator properties, used to treat asthma. Origin 1960s: from ter + butyl (elements of the systematic name), on the pattern of words such as isoprenaline …   English new terms dictionary

  • terbutaline — n. a bronchodilator drug: a short acting beta agonist (see sympathomimetic) used in the treatment of asthma and other respiratory disorders characterized by reversible airways obstruction. It may be given by mouth, injection, or inhalation;… …   The new mediacal dictionary

  • terbutaline — /teuhr byooht l een /, n. Pharm. a selective beta adrenergic receptor agonist substance, C12H19NO3, used in the treatment of asthma. [TER + BUT(YL) + AL3 + INE2] …   Useful english dictionary

  • terbutaline sulfate — A sympathomimetic drug with relatively selective B2 agonistic activity, used principally as a bronchodilator or tocolytic agent. * * * ter·bu·ta·line sul·fate (tər buґtə lēn) [USP] a β2 adrenergic receptor agonist, used as a… …   Medical dictionary

  • Тербуталин (Terbutaline) — бронхолитическое средство (см. Средство симпатомиметическое); применяется для лечения астмы, бронхита и других респираторных заболеваний. Может назначаться внутрь, в инъекциях или ингаляциях; возможные побочные эффекты включают: повышенную… …   Медицинские термины

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