Tryptase

Tryptase
Tryptase
Identifiers
EC number 3.4.21.59
CAS number 97501-93-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells that has been used as a marker for mast cell activation.[1][2] It is involved with allergenic response and is suspected to act as a mitogen for fibroblast lines. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions, but a negative test does not exclude anaphylaxis.

Genes

Human genes that encode proteins with tryptase activity include:

Gene Enzyme
TPSAB1 Tryptase alpha-1
TPSAB1 Tryptase beta-1
TPSB2 Tryptase beta-2
TPSD1 Tryptase delta
TPSG1 Tryptase gamma
PRSS22 Tryptase epsilon

References

  1. ^ Tanaka T, McRae BJ, Cho K, Cook R, Fraki JE, Johnson DA, Powers JC (November 1983). "Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates". J. Biol. Chem. 258 (22): 13552–7. PMID 6358206. 
  2. ^ Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH (May 1990). "Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family". Proc. Natl. Acad. Sci. U.S.A. 87 (10): 3811–5. doi:10.1073/pnas.87.10.3811. PMC 53993. PMID 2187193. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53993. 

External links