Tryptase

Tryptase
Identifiers
EC number	3.4.21.59
CAS number	97501-93-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells that has been used as a marker for mast cell activation.^[1][2] It is involved with allergenic response and is suspected to act as a mitogen for fibroblast lines. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions, but a negative test does not exclude anaphylaxis.

Genes

Human genes that encode proteins with tryptase activity include:

Gene	Enzyme
TPSAB1	Tryptase alpha-1
TPSAB1	Tryptase beta-1
TPSB2	Tryptase beta-2
TPSD1	Tryptase delta
TPSG1	Tryptase gamma
PRSS22	Tryptase epsilon

References

1. ^ Tanaka T, McRae BJ, Cho K, Cook R, Fraki JE, Johnson DA, Powers JC (November 1983). "Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates". J. Biol. Chem. 258 (22): 13552–7. PMID 6358206. 
2. ^ Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH (May 1990). "Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family". Proc. Natl. Acad. Sci. U.S.A. 87 (10): 3811–5. doi:10.1073/pnas.87.10.3811. PMC 53993. PMID 2187193. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53993. 

External links

• MeSH Tryptases

This hydrolase article is a stub. You can help Wikipedia by expanding it.v · Categories: EC 3.4.21 Hydrolase stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? The Sidewinder Sleeps Tonite Fruit and walnut salad Look at other dictionaries: Tryptase — Humane Beta Tryptase Tryptasen sind Enzyme, welche die Peptidbindung von Proteinen unter Verwendung eines katalytischen Serinrestes spalten. Sie gehören damit wie Trypsin zu den Serinproteasen und sind diesem ähnlich. Tryptasen werden in großer… …   Deutsch Wikipedia tryptase — tryp·tase trip .tās, .tāz n a protease of human mast cells that has been implicated as a pathological mediator of numerous allergic and inflammatory conditions (as asthma, rhinitis, and conjunctivitis) …   Medical dictionary TPSAB1 — Tryptase alpha/beta 1, also known as TPSAB1, is a human gene. PBB Summary section title = summary text = Tryptases comprise a family of trypsin like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin… …   Wikipedia TPSD1 — Tryptase delta 1, also known as TPSD1, is a human gene.cite web | title = Entrez Gene: TPSD1 tryptase delta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=23430| accessdate = ] PBB Summary section title …   Wikipedia GZMK — Granzyme K (granzyme 3; tryptase II), also known as GZMK, is a human gene.cite web | title = Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3003|… …   Wikipedia Allergiker — Allergischer Hautausschlag Als Allergie (griechisch αλλεργία, „die Fremdreaktion“, von altgriechisch ἄλλος allos, „anders, fremd“ und …   Deutsch Wikipedia Allergisch — Allergischer Hautausschlag Als Allergie (griechisch αλλεργία, „die Fremdreaktion“, von altgriechisch ἄλλος allos, „anders, fremd“ und …   Deutsch Wikipedia Allergische Reaktion — Allergischer Hautausschlag Als Allergie (griechisch αλλεργία, „die Fremdreaktion“, von altgriechisch ἄλλος allos, „anders, fremd“ und …   Deutsch Wikipedia Coombs-Gell-Klassifikation — Allergischer Hautausschlag Als Allergie (griechisch αλλεργία, „die Fremdreaktion“, von altgriechisch ἄλλος allos, „anders, fremd“ und …   Deutsch Wikipedia Fremdallergene — Allergischer Hautausschlag Als Allergie (griechisch αλλεργία, „die Fremdreaktion“, von altgriechisch ἄλλος allos, „anders, fremd“ und …   Deutsch Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”