KLK6

Kallikrein-related peptidase 6, also known as KLK6, is a human gene.cite web | title = Entrez Gene: KLK6 kallikrein-related peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5653| accessdate = ]

PBB_Summary
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summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.cite web | title = Entrez Gene: KLK6 kallikrein-related peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5653| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yousef GM, Kishi T, Diamandis EP |title=Role of kallikrein enzymes in the central nervous system. |journal=Clin. Chim. Acta |volume=329 |issue= 1-2 |pages= 1–8 |year= 2003 |pmid= 12589961 |doi=
*cite journal | author=Anisowicz A, Sotiropoulou G, Stenman G, "et al." |title=A novel protease homolog differentially expressed in breast and ovarian cancer. |journal=Mol. Med. |volume=2 |issue= 5 |pages= 624–36 |year= 1997 |pmid= 8898378 |doi=
*cite journal | author=Yamashiro K, Tsuruoka N, Kodama S, "et al." |title=Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. |journal=Biochim. Biophys. Acta |volume=1350 |issue= 1 |pages= 11–4 |year= 1997 |pmid= 9003450 |doi=
*cite journal | author=Little SP, Dixon EP, Norris F, "et al." |title=Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25135–42 |year= 1997 |pmid= 9312124 |doi=
*cite journal | author=Yousef GM, Luo LY, Scherer SW, "et al." |title=Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease. |journal=Genomics |volume=62 |issue= 2 |pages= 251–9 |year= 2000 |pmid= 10610719 |doi= 10.1006/geno.1999.6012
*cite journal | author=Gan L, Lee I, Smith R, "et al." |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11054574 |doi=
*cite journal | author=Petraki CD, Karavana VN, Skoufogiannis PT, "et al." |title=The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. |journal=J. Histochem. Cytochem. |volume=49 |issue= 11 |pages= 1431–41 |year= 2001 |pmid= 11668196 |doi=
*cite journal | author=Bernett MJ, Blaber SI, Scarisbrick IA, "et al." |title=Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24562–70 |year= 2002 |pmid= 11983703 |doi= 10.1074/jbc.M202392200
*cite journal | author=Gomis-Rüth FX, Bayés A, Sotiropoulou G, "et al." |title=The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27273–81 |year= 2002 |pmid= 12016211 |doi= 10.1074/jbc.M201534200
*cite journal | author=Scarisbrick IA, Blaber SI, Lucchinetti CF, "et al." |title=Activity of a newly identified serine protease in CNS demyelination. |journal=Brain |volume=125 |issue= Pt 6 |pages= 1283–96 |year= 2002 |pmid= 12023317 |doi=
*cite journal | author=Zarghooni M, Soosaipillai A, Grass L, "et al." |title=Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients. |journal=Clin. Biochem. |volume=35 |issue= 3 |pages= 225–31 |year= 2002 |pmid= 12074831 |doi=
*cite journal | author=Hoffman BR, Katsaros D, Scorilas A, "et al." |title=Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker. |journal=Br. J. Cancer |volume=87 |issue= 7 |pages= 763–71 |year= 2002 |pmid= 12232761 |doi= 10.1038/sj.bjc.6600533
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mitsui S, Okui A, Uemura H, "et al." |title=Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease. |journal=Ann. N. Y. Acad. Sci. |volume=977 |issue= |pages= 216–23 |year= 2003 |pmid= 12480753 |doi=
*cite journal | author=Hutchinson S, Luo LY, Yousef GM, "et al." |title=Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin. |journal=Clin. Chem. |volume=49 |issue= 5 |pages= 746–51 |year= 2003 |pmid= 12709365 |doi=
*cite journal | author=Magklara A, Mellati AA, Wasney GA, "et al." |title=Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 4 |pages= 948–55 |year= 2003 |pmid= 12878203 |doi=
*cite journal | author=Iwata A, Maruyama M, Akagi T, "et al." |title=Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. |journal=Hum. Mol. Genet. |volume=12 |issue= 20 |pages= 2625–35 |year= 2004 |pmid= 12928483 |doi= 10.1093/hmg/ddg283
*cite journal | author=Sauter ER, Lininger J, Magklara A, "et al." |title=Association of kallikrein expression in nipple aspirate fluid with breast cancer risk. |journal=Int. J. Cancer |volume=108 |issue= 4 |pages= 588–91 |year= 2004 |pmid= 14696124 |doi= 10.1002/ijc.11607
*cite journal | author=Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G |title=Cloning and characterization of novel isoforms of the human kallikrein 6 gene. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 1 |pages= 54–61 |year= 2004 |pmid= 15207701 |doi= 10.1016/j.bbrc.2004.04.205

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