TPSD1

Tryptase delta 1, also known as TPSD1, is a human gene.cite web | title = Entrez Gene: TPSD1 tryptase delta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23430| accessdate = ]

PBB_Summary
section_title =
summary_text = Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.cite web | title = Entrez Gene: TPSD1 tryptase delta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23430| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Caughey GH |title=Tryptase genetics and anaphylaxis. |journal=J. Allergy Clin. Immunol. |volume=117 |issue= 6 |pages= 1411–4 |year= 2006 |pmid= 16751005 |doi= 10.1016/j.jaci.2006.02.026
*cite journal | author=Caughey GH |title=New developments in the genetics and activation of mast cell proteases. |journal=Mol. Immunol. |volume=38 |issue= 16-18 |pages= 1353–7 |year= 2003 |pmid= 12217407 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang HW, McNeil HP, Husain A, "et al." |title=Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activity. |journal=J. Immunol. |volume=169 |issue= 9 |pages= 5145–52 |year= 2002 |pmid= 12391231 |doi=
*cite journal | author=Soto D, Malmsten C, Blount JL, "et al." |title=Genetic deficiency of human mast cell alpha-tryptase. |journal=Clin. Exp. Allergy |volume=32 |issue= 7 |pages= 1000–6 |year= 2003 |pmid= 12100045 |doi=
*cite journal | author=Min HK, Kambe N, Schwartz LB |title=Human mouse mast cell protease 7-like tryptase genes are pseudogenes. |journal=J. Allergy Clin. Immunol. |volume=107 |issue= 2 |pages= 315–21 |year= 2001 |pmid= 11174199 |doi= 10.1067/mai.2001.112130
*cite journal | author=Daniels RJ, Peden JF, Lloyd C, "et al." |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=
*cite journal | author=Pallaoro M, Fejzo MS, Shayesteh L, "et al." |title=Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3355–62 |year= 1999 |pmid= 9920877 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes