KLK5

Kallikrein-related peptidase 5, also known as KLK5, is a human gene.cite web | title = Entrez Gene: KLK5 kallikrein-related peptidase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25818| accessdate = ]

PBB_Summary
section_title =
summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.cite web | title = Entrez Gene: KLK5 kallikrein-related peptidase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25818| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Diamandis EP, Yousef GM, Luo LY, "et al." |title=The new human kallikrein gene family: implications in carcinogenesis. |journal=Trends Endocrinol. Metab. |volume=11 |issue= 2 |pages= 54–60 |year= 2001 |pmid= 10675891 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Brattsand M, Egelrud T |title=Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30033–40 |year= 1999 |pmid= 10514489 |doi=
*cite journal | author=Yousef GM, Diamandis EP |title=The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37511–6 |year= 2000 |pmid= 10608802 |doi=
*cite journal | author=Yousef GM, Luo LY, Diamandis EP |title=Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. |journal=Anticancer Res. |volume=19 |issue= 4B |pages= 2843–52 |year= 2000 |pmid= 10652563 |doi=
*cite journal | author=Harvey TJ, Hooper JD, Myers SA, "et al." |title=Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37397–406 |year= 2001 |pmid= 10969073 |doi= 10.1074/jbc.M004525200
*cite journal | author=Gan L, Lee I, Smith R, "et al." |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11054574 |doi=
*cite journal | author=Kim H, Scorilas A, Katsaros D, "et al." |title=Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer. |journal=Br. J. Cancer |volume=84 |issue= 5 |pages= 643–50 |year= 2001 |pmid= 11237385 |doi= 10.1054/bjoc.2000.1649
*cite journal | author=Yousef GM, Scorilas A, Chang A, "et al." |title=Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues. |journal=Prostate |volume=51 |issue= 2 |pages= 126–32 |year= 2002 |pmid= 11948967 |doi= 10.1002/pros.10067
*cite journal | author=Yousef GM, Obiezu CV, Jung K, "et al." |title=Differential expression of Kallikrein gene 5 in cancerous and normal testicular tissues. |journal=Urology |volume=60 |issue= 4 |pages= 714–8 |year= 2003 |pmid= 12385949 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dong Y, Kaushal A, Brattsand M, "et al." |title=Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. |journal=Clin. Cancer Res. |volume=9 |issue= 5 |pages= 1710–20 |year= 2004 |pmid= 12738725 |doi=
*cite journal | author=Yousef GM, Kapadia C, Polymeris ME, "et al." |title=The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids. |journal=Biochim. Biophys. Acta |volume=1628 |issue= 2 |pages= 88–96 |year= 2003 |pmid= 12890555 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Caubet C, Jonca N, Brattsand M, "et al." |title=Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1235–44 |year= 2004 |pmid= 15140227 |doi= 10.1111/j.0022-202X.2004.22512.x
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Brattsand M, Stefansson K, Lundh C, "et al." |title=A proteolytic cascade of kallikreins in the stratum corneum. |journal=J. Invest. Dermatol. |volume=124 |issue= 1 |pages= 198–203 |year= 2005 |pmid= 15654974 |doi= 10.1111/j.0022-202X.2004.23547.x
*cite journal | author=Ishida-Yamamoto A, Deraison C, Bonnart C, "et al." |title=LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum. |journal=J. Invest. Dermatol. |volume=124 |issue= 2 |pages= 360–6 |year= 2005 |pmid= 15675955 |doi= 10.1111/j.0022-202X.2004.23583.x

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