KLK7

Kallikrein-related peptidase 7, also known as KLK7, is a human gene.cite web | title = Entrez Gene: KLK7 kallikrein-related peptidase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5650| accessdate = ]

PBB_Summary
section_title =
summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded enzyme is thought to be involved in the proteolysis of intercellular cohesive structures preceding desquamation, which is the shedding of the outermost layer of the epidermis. Alternative splicing of this gene results in two transcript variants encoding the same protein.cite web | title = Entrez Gene: KLK7 kallikrein-related peptidase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5650| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Skytt A, Strömqvist M, Egelrud T |title=Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 2 |pages= 586–9 |year= 1995 |pmid= 7794273 |doi= 10.1006/bbrc.1995.1853
*cite journal | author=Hansson L, Strömqvist M, Bäckman A, "et al." |title=Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. |journal=J. Biol. Chem. |volume=269 |issue= 30 |pages= 19420–6 |year= 1994 |pmid= 8034709 |doi=
*cite journal | author=Yousef GM, Scorilas A, Magklara A, "et al." |title=The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation. |journal=Gene |volume=254 |issue= 1-2 |pages= 119–28 |year= 2000 |pmid= 10974542 |doi=
*cite journal | author=Gan L, Lee I, Smith R, "et al." |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11054574 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dong Y, Kaushal A, Brattsand M, "et al." |title=Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. |journal=Clin. Cancer Res. |volume=9 |issue= 5 |pages= 1710–20 |year= 2004 |pmid= 12738725 |doi=
*cite journal | author=Talieri M, Diamandis EP, Gourgiotis D, "et al." |title=Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma. |journal=Thromb. Haemost. |volume=91 |issue= 1 |pages= 180–6 |year= 2004 |pmid= 14691584 |doi= 10.1267/THRO04010180
*cite journal | author=Diamandis EP, Scorilas A, Kishi T, "et al." |title=Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia. |journal=Clin. Biochem. |volume=37 |issue= 3 |pages= 230–7 |year= 2004 |pmid= 14972646 |doi= 10.1016/j.clinbiochem.2003.11.012
*cite journal | author=Caubet C, Jonca N, Brattsand M, "et al." |title=Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1235–44 |year= 2004 |pmid= 15140227 |doi= 10.1111/j.0022-202X.2004.22512.x
*cite journal | author=Vasilopoulos Y, Cork MJ, Murphy R, "et al." |title=Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. |journal=J. Invest. Dermatol. |volume=123 |issue= 1 |pages= 62–6 |year= 2004 |pmid= 15191543 |doi= 10.1111/j.0022-202X.2004.22708.x
*cite journal | author=Santin AD, Cane' S, Bellone S, "et al." |title=The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells. |journal=Gynecol. Oncol. |volume=94 |issue= 2 |pages= 283–8 |year= 2004 |pmid= 15297163 |doi= 10.1016/j.ygyno.2004.05.023
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ishida-Yamamoto A, Deraison C, Bonnart C, "et al." |title=LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum. |journal=J. Invest. Dermatol. |volume=124 |issue= 2 |pages= 360–6 |year= 2005 |pmid= 15675955 |doi= 10.1111/j.0022-202X.2004.23583.x
*cite journal | author=Planque C, de Monte M, Guyetant S, "et al." |title=KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer. |journal=Biochem. Biophys. Res. Commun. |volume=329 |issue= 4 |pages= 1260–6 |year= 2005 |pmid= 15766562 |doi= 10.1016/j.bbrc.2005.02.100
*cite journal | author=Descargues P, Deraison C, Prost C, "et al." |title=Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome. |journal=J. Invest. Dermatol. |volume=126 |issue= 7 |pages= 1622–32 |year= 2006 |pmid= 16628198 |doi= 10.1038/sj.jid.5700284
*cite journal | author= |title=Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 635–824 |year= 2006 |pmid= 16800723 |doi= 10.1515/BC.2006.081
*cite journal | author=Lundwall A, Band V, Blaber M, "et al." |title=A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 637–41 |year= 2006 |pmid= 16800724 |doi= 10.1515/BC.2006.082
*cite journal | author=Yamasaki K, Schauber J, Coda A, "et al." |title=Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. |journal=FASEB J. |volume=20 |issue= 12 |pages= 2068–80 |year= 2006 |pmid= 17012259 |doi= 10.1096/fj.06-6075com
*cite journal | author=Debela M, Hess P, Magdolen V, "et al." |title=Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 41 |pages= 16086–91 |year= 2007 |pmid= 17909180 |doi= 10.1073/pnas.0707811104

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