Cathepsin G

Cathepsin G

Cathepsin G, also known as CTSG, is a human gene.

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summary_text = The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [cite web | title = Entrez Gene: CTSG cathepsin G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1511| accessdate = ]

References

Further reading

PBB_Further_reading
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*cite journal | author=Shafer WM, Katzif S, Bowers S, "et al." |title=Tailoring an antibacterial peptide of human lysosomal cathepsin G to enhance its broad-spectrum action against antibiotic-resistant bacterial pathogens. |journal=Curr. Pharm. Des. |volume=8 |issue= 9 |pages= 695–702 |year= 2002 |pmid= 11945165 |doi=
*cite journal | author=Cohen AB, Stevens MD, Miller EJ, "et al." |title=Generation of the neutrophil-activating peptide-2 by cathepsin G and cathepsin G-treated human platelets. |journal=Am. J. Physiol. |volume=263 |issue= 2 Pt 1 |pages= L249–56 |year= 1992 |pmid= 1387511 |doi=
*cite journal | author=Sasaki T, Ueno-Matsuda E |title=Immunocytochemical localization of cathepsins B and G in odontoclasts of human deciduous teeth. |journal=J. Dent. Res. |volume=71 |issue= 12 |pages= 1881–4 |year= 1993 |pmid= 1452887 |doi=
*cite journal | author=Maison CM, Villiers CL, Colomb MG |title=Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G. |journal=J. Immunol. |volume=147 |issue= 3 |pages= 921–6 |year= 1991 |pmid= 1861080 |doi=
*cite journal | author=Brandt E, Van Damme J, Flad HD |title=Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived connective tissue-activating peptide III. |journal=Cytokine |volume=3 |issue= 4 |pages= 311–21 |year= 1991 |pmid= 1873479 |doi=
*cite journal | author=Kargi HA, Campbell EJ, Kuhn C |title=Elastase and cathepsin G of human monocytes: heterogeneity and subcellular localization to peroxidase-positive granules. |journal=J. Histochem. Cytochem. |volume=38 |issue= 8 |pages= 1179–86 |year= 1990 |pmid= 2164060 |doi=
*cite journal | author=Pratt CW, Tobin RB, Church FC |title=Interaction of heparin cofactor II with neutrophil elastase and cathepsin G. |journal=J. Biol. Chem. |volume=265 |issue= 11 |pages= 6092–7 |year= 1990 |pmid= 2318847 |doi=
*cite journal | author=Gabay JE, Scott RW, Campanelli D, "et al." |title=Antibiotic proteins of human polymorphonuclear leukocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 14 |pages= 5610–4 |year= 1989 |pmid= 2501794 |doi=
*cite journal | author=Hohn PA, Popescu NC, Hanson RD, "et al." |title=Genomic organization and chromosomal localization of the human cathepsin G gene. |journal=J. Biol. Chem. |volume=264 |issue= 23 |pages= 13412–9 |year= 1989 |pmid= 2569462 |doi=
*cite journal | author=Livesey SA, Buescher ES, Krannig GL, "et al." |title=Human neutrophil granule heterogeneity: immunolocalization studies using cryofixed, dried and embedded specimens. |journal=Scanning Microsc. Suppl. |volume=3 |issue= |pages= 231–9; discussion 239–40 |year= 1990 |pmid= 2616953 |doi=
*cite journal | author=Campbell EJ, Silverman EK, Campbell MA |title=Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity. |journal=J. Immunol. |volume=143 |issue= 9 |pages= 2961–8 |year= 1989 |pmid= 2681419 |doi=
*cite journal | author=Salvesen G, Farley D, Shuman J, "et al." |title=Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases. |journal=Biochemistry |volume=26 |issue= 8 |pages= 2289–93 |year= 1987 |pmid= 3304423 |doi=
*cite journal | author=Heck LW, Rostand KS, Hunter FA, Bhown A |title=Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil cathepsin G from normal donors. |journal=Anal. Biochem. |volume=158 |issue= 1 |pages= 217–27 |year= 1987 |pmid= 3799965 |doi=
*cite journal | author=Crocker J, Jenkins R, Burnett D |title=Immunohistochemical localization of cathepsin G in human tissues. |journal=Am. J. Surg. Pathol. |volume=9 |issue= 5 |pages= 338–43 |year= 1986 |pmid= 3911778 |doi=
*cite journal | author=Klickstein LB, Kaempfer CE, Wintroub BU |title=The granulocyte-angiotensin system. Angiotensin I-converting activity of cathepsin G. |journal=J. Biol. Chem. |volume=257 |issue= 24 |pages= 15042–6 |year= 1983 |pmid= 6294088 |doi=
*cite journal | author=LaRosa CA, Rohrer MJ, Benoit SE, "et al." |title=Neutrophil cathepsin G modulates the platelet surface expression of the glycoprotein (GP) Ib-IX complex by proteolysis of the von Willebrand factor binding site on GPIb alpha and by a cytoskeletal-mediated redistribution of the remainder of the complex. |journal=Blood |volume=84 |issue= 1 |pages= 158–68 |year= 1994 |pmid= 7517206 |doi=
*cite journal | author=Owen CA, Campbell MA, Sannes PL, "et al." |title=Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. |journal=J. Cell Biol. |volume=131 |issue= 3 |pages= 775–89 |year= 1995 |pmid= 7593196 |doi=
*cite journal | author=Savage MJ, Iqbal M, Loh T, "et al." |title=Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein. |journal=Neuroscience |volume=60 |issue= 3 |pages= 607–19 |year= 1994 |pmid= 7936190 |doi=
*cite journal | author=Grisolano JL, Sclar GM, Ley TJ |title=Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 19 |pages= 8989–93 |year= 1994 |pmid= 8090757 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=

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