Cathepsin B

Cathepsin B

Cathepsin B, also known as CTSB, is a human gene.

Function

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of β-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade β-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease. [cite journal |author=Mueller-Steiner S, Zhou Y, Arai H, Roberson E, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L |title=Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease |journal=Neuron |volume=51 |issue=6 |pages=703–14 |year=2006 |pmid=16982417 |doi=10.1016/j.neuron.2006.07.027] [cite web |url=http://www.scienceblog.com/cms/enzyme-shreds-alzheimers-protein-11550.html |title=Enzyme shreds Alzheimer's protein | Science Blog |accessdate=2007-11-07 |date=2006-09-21] . Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [cite web | title = Entrez Gene: CTSB cathepsin B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1508| accessdate = ]

ee also

*Cathepsins

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yan S, Sloane BF |title=Molecular regulation of human cathepsin B: implication in pathologies. |journal=Biol. Chem. |volume=384 |issue= 6 |pages= 845–54 |year= 2004 |pmid= 12887051 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Cathepsin C — PDB rendering based on 1k3b …   Wikipedia

  • Cathepsin K — Cathepsin K, also known as CTSK, is a human enzyme controlled by a gene.cite web | title = Entrez Gene: CTSK cathepsin K| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1513| accessdate = ] Cathepsin K is a …   Wikipedia

  • Cathepsin G — Cathepsin G, also known as CTSG, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear… …   Wikipedia

  • Cathepsin S — Cathepsin S, also known as CTSS, is a human gene.cite web | title = Entrez Gene: CTSS cathepsin S| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1520| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • Cathepsin A — Cathepsin A, also known as CTSA, is a human gene.cite web | title = Entrez Gene: CTSA cathepsin A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5476| accessdate = ] PBB Summary section title = summary… …   Wikipedia

  • cathepsin — [kə thep′sin] n. [< Gr kathepsein, boil down, soften < kata , down (see CATA ) + hepsein, boil + IN1] any of several intracellular enzymes that act as catalysts in the breakdown of protein …   English World dictionary

  • Cathepsin — A cathepsin (Union of two Greek words, kata :down and hepsein:boil) is a cysteine or aspartic protease, a type of protein that breaks apart other proteins, found in many types of cells including those in all animals. There are approximately a… …   Wikipedia

  • Cathepsin — Bändermodell des Cathepsin K. Cathepsine (auch Kat(h)epsine von griech. καθεψειν verdauen) sind Proteasen, die beispielsweise in Lysosomen, eosinophilen Granulozyten und Osteoklasten zu finden sind und einen hydrolytischen Abbau der… …   Deutsch Wikipedia

  • cathepsin — noun Etymology: Greek kathepsein to digest (from kata cata + hepsein to boil) + English 2 in Date: 1929 any of several intracellular proteases of animal tissue that aid in autolysis …   New Collegiate Dictionary

  • cathepsin — catheptic /keuh thep tik/, adj. /keuh thep sin/, n. Biochem. any of a class of intracellular proteolytic enzymes, occurring in animal tissue, esp. the liver, spleen, kidneys, and intestine, that catalyze autolysis in certain pathological… …   Universalium

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”