- Cathepsin B
Cathepsin B, also known as CTSB, is a human
gene .Function
PBB_Summary
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summary_text = The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of β-amyloid precursor protein into the amyloid plaques found inAlzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade β-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease. [cite journal |author=Mueller-Steiner S, Zhou Y, Arai H, Roberson E, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L |title=Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease |journal=Neuron |volume=51 |issue=6 |pages=703–14 |year=2006 |pmid=16982417 |doi=10.1016/j.neuron.2006.07.027] [cite web |url=http://www.scienceblog.com/cms/enzyme-shreds-alzheimers-protein-11550.html |title=Enzyme shreds Alzheimer's protein | Science Blog |accessdate=2007-11-07 |date=2006-09-21] . Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [cite web | title = Entrez Gene: CTSB cathepsin B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1508| accessdate = ]ee also
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Cathepsin sReferences
Further reading
PBB_Further_reading
citations =
*cite journal | author=Yan S, Sloane BF |title=Molecular regulation of human cathepsin B: implication in pathologies. |journal=Biol. Chem. |volume=384 |issue= 6 |pages= 845–54 |year= 2004 |pmid= 12887051 |doi=External links
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