Cathepsin A

Cathepsin A

Cathepsin A, also known as CTSA, is a human gene.cite web | title = Entrez Gene: CTSA cathepsin A| url =| accessdate = ]

section_title =
summary_text = This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis.cite web | title = Entrez Gene: CTSA cathepsin A| url =| accessdate = ]

Cathepsin A is a enzyme which is classified both as a cathepsin and a carboxypeptidase.


More details on Cathepsin A can be found from [ Human Cathepsin Database]

Further reading

citations =
*cite journal | author=Morreau H, Galjart NJ, Willemsen R, "et al." |title=Human lysosomal protective protein. Glycosylation, intracellular transport, and association with beta-galactosidase in the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 17949–56 |year= 1992 |pmid= 1387645 |doi=
*cite journal | author=Halal F, Chitayat D, Parikh H, "et al." |title=Ring chromosome 20 and possible assignment of the structural gene encoding human carboxypeptidase-L to the distal segment of the long arm of chromosome 20. |journal=Am. J. Med. Genet. |volume=43 |issue= 3 |pages= 576–9 |year= 1992 |pmid= 1605251 |doi= 10.1002/ajmg.1320430314
*cite journal | author=Jackman HL, Tan FL, Tamei H, "et al." |title=A peptidase in human platelets that deamidates tachykinins. Probable identity with the lysosomal "protective protein". |journal=J. Biol. Chem. |volume=265 |issue= 19 |pages= 11265–72 |year= 1990 |pmid= 1694176 |doi=
*cite journal | author=Zhou XY, Galjart NJ, Willemsen R, "et al." |title=A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable. |journal=EMBO J. |volume=10 |issue= 13 |pages= 4041–8 |year= 1992 |pmid= 1756715 |doi=
*cite journal | author=Galjart NJ, Morreau H, Willemsen R, "et al." |title=Human lysosomal protective protein has cathepsin A-like activity distinct from its protective function. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14754–62 |year= 1991 |pmid= 1907282 |doi=
*cite journal | author=Yoshida K, Oshima A, Shimmoto M, "et al." |title=Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases. |journal=Am. J. Hum. Genet. |volume=49 |issue= 2 |pages= 435–42 |year= 1991 |pmid= 1907800 |doi=
*cite journal | author=Wiegant J, Galjart NJ, Raap AK, d'Azzo A |title=The gene encoding human protective protein (PPGB) is on chromosome 20. |journal=Genomics |volume=10 |issue= 2 |pages= 345–9 |year= 1991 |pmid= 2071143 |doi=
*cite journal | author=Strisciuglio P, Sly WS, Dodson WE, "et al." |title=Combined deficiency of beta-galactosidase and neuraminidase: natural history of the disease in the first 18 years of an American patient with late infantile onset form. |journal=Am. J. Med. Genet. |volume=37 |issue= 4 |pages= 573–7 |year= 1991 |pmid= 2148053 |doi= 10.1002/ajmg.1320370431
*cite journal | author=Kase R, Itoh K, Takiyama N, "et al." |title=Galactosialidosis: simultaneous deficiency of esterase, carboxy-terminal deamidase and acid carboxypeptidase activities. |journal=Biochem. Biophys. Res. Commun. |volume=172 |issue= 3 |pages= 1175–9 |year= 1990 |pmid= 2244901 |doi=
*cite journal | author=Willemsen R, Hoogeveen AT, Sips HJ, "et al." |title=Immunoelectron microscopical localization of lysosomal beta-galactosidase and its precursor forms in normal and mutant human fibroblasts. |journal=Eur. J. Cell Biol. |volume=40 |issue= 1 |pages= 9–15 |year= 1986 |pmid= 3084261 |doi=
*cite journal | author=Verheijen FW, Palmeri S, Galjaard H |title=Purification and partial characterization of lysosomal neuraminidase from human placenta. |journal=Eur. J. Biochem. |volume=162 |issue= 1 |pages= 63–7 |year= 1987 |pmid= 3102233 |doi=
*cite journal | author=Nanba E, Tsuji A, Omura K, Suzuki Y |title=Galactosialidosis: a direct evidence that a 46-kilodalton protein restores deficient enzyme activities in fibroblasts. |journal=Biochem. Biophys. Res. Commun. |volume=144 |issue= 1 |pages= 138–42 |year= 1987 |pmid= 3107551 |doi=
*cite journal | author=Galjart NJ, Gillemans N, Harris A, "et al." |title=Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases. |journal=Cell |volume=54 |issue= 6 |pages= 755–64 |year= 1988 |pmid= 3136930 |doi=
*cite journal | author=Chitayat D, Applegarth DA, Lewis J, "et al." |title=Juvenile galactosialidosis in a white male: a new variant. |journal=Am. J. Med. Genet. |volume=31 |issue= 4 |pages= 887–901 |year= 1989 |pmid= 3149149 |doi= 10.1002/ajmg.1320310423
*cite journal | author=Verheijen FW, Palmeri S, Hoogeveen AT, Galjaard H |title=Human placental neuraminidase. Activation, stabilization and association with beta-galactosidase and its protective protein. |journal=Eur. J. Biochem. |volume=149 |issue= 2 |pages= 315–21 |year= 1985 |pmid= 3922758 |doi=
*cite journal | author=van der Horst GT, Kleijer WJ, Hoogeveen AT, "et al." |title=Morquio B syndrome: a primary defect in beta-galactosidase. |journal=Am. J. Med. Genet. |volume=16 |issue= 2 |pages= 261–75 |year= 1984 |pmid= 6418007 |doi= 10.1002/ajmg.1320160215
*cite journal | author=Maire I, Nivelon-Chevallier AR |title=Combined deficiency of beta-galactosidase and neuraminidase: three affected siblings in a French family. |journal=J. Inherit. Metab. Dis. |volume=4 |issue= 4 |pages= 221–3 |year= 1982 |pmid= 6796775 |doi=
*cite journal | author=Pshezhetsky AV, Potier M |title=Direct affinity purification and supramolecular organization of human lysosomal cathepsin A. |journal=Arch. Biochem. Biophys. |volume=313 |issue= 1 |pages= 64–70 |year= 1994 |pmid= 8053688 |doi= 10.1006/abbi.1994.1359
*cite journal | author=Ishii N, Oshima A, Sakuraba H, "et al." |title=Normal serum beta-galactosidase in juvenile GM1 gangliosidosis. |journal=Pediatr. Neurol. |volume=10 |issue= 4 |pages= 317–9 |year= 1994 |pmid= 8068159 |doi=
*cite journal | author=Chakraborty S, Rafi MA, Wenger DA |title=Mutations in the lysosomal beta-galactosidase gene that cause the adult form of GM1 gangliosidosis. |journal=Am. J. Hum. Genet. |volume=54 |issue= 6 |pages= 1004–13 |year= 1994 |pmid= 8198123 |doi=

External links

* [ HuCAD-Human Cathepsin Database]

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