- KLK10
Kallikrein-related peptidase 10, also known as KLK10, is a human
gene .cite web | title = Entrez Gene: KLK10 kallikrein-related peptidase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5655| accessdate = ]PBB_Summary
section_title =
summary_text = Kallikreins are a subgroup ofserine protease s having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated incarcinogenesis and some have potential as novelcancer and other diseasebiomarker s. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression oftumorigenesis in breast andprostate cancer s. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.cite web | title = Entrez Gene: KLK10 kallikrein-related peptidase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5655| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Diamandis EP, Yousef GM, Luo LY, "et al." |title=The new human kallikrein gene family: implications in carcinogenesis. |journal=Trends Endocrinol. Metab. |volume=11 |issue= 2 |pages= 54–60 |year= 2001 |pmid= 10675891 |doi=
*cite journal | author=Zhang Y, Bhat I, Zeng M, "et al." |title=Human kallikrein 10, a predictive marker for breast cancer. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 715–21 |year= 2006 |pmid= 16800732 |doi= 10.1515/BC.2006.090
*cite journal | author=Liu XL, Wazer DE, Watanabe K, Band V |title=Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. |journal=Cancer Res. |volume=56 |issue= 14 |pages= 3371–9 |year= 1996 |pmid= 8764136 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Polikoff D, Kuo WL, Cochran JF, "et al." |title=Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 147–8 |year= 1998 |pmid= 9533035 |doi=
*cite journal | author=Luo L, Herbrick JA, Scherer SW, "et al." |title=Structural characterization and mapping of the normal epithelial cell-specific 1 gene. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 3 |pages= 580–6 |year= 1998 |pmid= 9647736 |doi= 10.1006/bbrc.1998.8793
*cite journal | author=Goyal J, Smith KM, Cowan JM, "et al." |title=The role for NES1 serine protease as a novel tumor suppressor. |journal=Cancer Res. |volume=58 |issue= 21 |pages= 4782–6 |year= 1998 |pmid= 9809976 |doi=
*cite journal | author=Harvey TJ, Hooper JD, Myers SA, "et al." |title=Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37397–406 |year= 2001 |pmid= 10969073 |doi= 10.1074/jbc.M004525200
*cite journal | author=Gan L, Lee I, Smith R, "et al." |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11054574 |doi=
*cite journal | author=Dhar S, Bhargava R, Yunes M, "et al." |title=Analysis of normal epithelial cell specific-1 (NES1)/kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer. |journal=Clin. Cancer Res. |volume=7 |issue= 11 |pages= 3393–8 |year= 2002 |pmid= 11705853 |doi=
*cite journal | author=Bharaj BB, Luo LY, Jung K, "et al." |title=Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers. |journal=Prostate |volume=51 |issue= 1 |pages= 35–41 |year= 2002 |pmid= 11920956 |doi=
*cite journal | author=Luo LY, Diamandis EP, Look MP, "et al." |title=Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance. |journal=Br. J. Cancer |volume=86 |issue= 11 |pages= 1790–6 |year= 2002 |pmid= 12087468 |doi= 10.1038/sj.bjc.6600323
*cite journal | author=Petraki CD, Karavana VN, Luo LY, Diamandis EP |title=Human kallikrein 10 expression in normal tissues by immunohistochemistry. |journal=J. Histochem. Cytochem. |volume=50 |issue= 9 |pages= 1247–61 |year= 2002 |pmid= 12185203 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Petraki CD, Gregorakis AK, Papanastasiou PA, "et al." |title=Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues. |journal=Prostate Cancer Prostatic Dis. |volume=6 |issue= 3 |pages= 223–7 |year= 2004 |pmid= 12970725 |doi= 10.1038/sj.pcan.4500674
*cite journal | author=Sauter ER, Lininger J, Magklara A, "et al." |title=Association of kallikrein expression in nipple aspirate fluid with breast cancer risk. |journal=Int. J. Cancer |volume=108 |issue= 4 |pages= 588–91 |year= 2004 |pmid= 14696124 |doi= 10.1002/ijc.11607
*cite journal | author=Diamandis EP, Scorilas A, Kishi T, "et al." |title=Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia. |journal=Clin. Biochem. |volume=37 |issue= 3 |pages= 230–7 |year= 2004 |pmid= 14972646 |doi= 10.1016/j.clinbiochem.2003.11.012
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504PBB_Controls
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