- KLK8
Kallikrein-related peptidase 8, also known as KLK8, is a human
gene .cite web | title = Entrez Gene: KLK8 kallikrein-related peptidase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11202| accessdate = ]PBB_Summary
section_title =
summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.cite web | title = Entrez Gene: KLK8 kallikrein-related peptidase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11202| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Yoshida S, Taniguchi M, Hirata A, Shiosaka S |title=Sequence analysis and expression of human neuropsin cDNA and gene. |journal=Gene |volume=213 |issue= 1-2 |pages= 9–16 |year= 1998 |pmid= 9714609 |doi=
*cite journal | author=Mitsui S, Tsuruoka N, Yamashiro K, "et al." |title=A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain. |journal=Eur. J. Biochem. |volume=260 |issue= 3 |pages= 627–34 |year= 1999 |pmid= 10102990 |doi=
*cite journal | author=Underwood LJ, Tanimoto H, Wang Y, "et al." |title=Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma. |journal=Cancer Res. |volume=59 |issue= 17 |pages= 4435–9 |year= 1999 |pmid= 10485494 |doi=
*cite journal | author=Harvey TJ, Hooper JD, Myers SA, "et al." |title=Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37397–406 |year= 2001 |pmid= 10969073 |doi= 10.1074/jbc.M004525200
*cite journal | author=Gan L, Lee I, Smith R, "et al." |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11054574 |doi=
*cite journal | author=Magklara A, Scorilas A, Katsaros D, "et al." |title=The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. |journal=Clin. Cancer Res. |volume=7 |issue= 4 |pages= 806–11 |year= 2001 |pmid= 11309326 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Cané S, Bignotti E, Bellone S, "et al." |title=The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer. |journal=Am. J. Obstet. Gynecol. |volume=190 |issue= 1 |pages= 60–6 |year= 2004 |pmid= 14749636 |doi= 10.1016/j.ajog.2003.07.020
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Shigemasa K, Tian X, Gu L, "et al." |title=Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer. |journal=Oncol. Rep. |volume=11 |issue= 6 |pages= 1153–9 |year= 2004 |pmid= 15138549 |doi=
*cite journal | author=Li Y, Qian YP, Yu XJ, "et al." |title=Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory. |journal=Mol. Biol. Evol. |volume=21 |issue= 11 |pages= 2111–5 |year= 2005 |pmid= 15282331 |doi= 10.1093/molbev/msh220
*cite journal | author=Rajapakse S, Ogiwara K, Takano N, "et al." |title=Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins. |journal=FEBS Lett. |volume=579 |issue= 30 |pages= 6879–84 |year= 2006 |pmid= 16337200 |doi= 10.1016/j.febslet.2005.11.039
*cite journal | author= |title=Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 635–824 |year= 2006 |pmid= 16800723 |doi= 10.1515/BC.2006.081
*cite journal | author=Lundwall A, Band V, Blaber M, "et al." |title=A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 637–41 |year= 2006 |pmid= 16800724 |doi= 10.1515/BC.2006.082
*cite journal | author=Kishi T, Cloutier SM, Kündig C, "et al." |title=Activation and enzymatic characterization of recombinant human kallikrein 8. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 723–31 |year= 2006 |pmid= 16800733 |doi= 10.1515/BC.2006.091
*cite journal | author=Sher YP, Chou CC, Chou RH, "et al." |title=Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11763–70 |year= 2007 |pmid= 17178872 |doi= 10.1158/0008-5472.CAN-06-3165
*cite journal | author=Lu ZX, Peng J, Su B |title=A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory. |journal=Hum. Mutat. |volume=28 |issue= 10 |pages= 978–84 |year= 2007 |pmid= 17487847 |doi= 10.1002/humu.20547PBB_Controls
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