GZMK

Granzyme K (granzyme 3; tryptase II), also known as GZMK, is a human gene.cite web | title = Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3003| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.cite web | title = Entrez Gene: GZMK granzyme K (granzyme 3; tryptase II)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3003| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Smyth MJ, O'Connor MD, Trapani JA |title=Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies. |journal=J. Leukoc. Biol. |volume=60 |issue= 5 |pages= 555–62 |year= 1996 |pmid= 8929545 |doi=
*cite journal | author=Shi L, Kam CM, Powers JC, "et al." |title=Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. |journal=J. Exp. Med. |volume=176 |issue= 6 |pages= 1521–9 |year= 1993 |pmid= 1460416 |doi=
*cite journal | author=Hameed A, Lowrey DM, Lichtenheld M, Podack ER |title=Characterization of three serine esterases isolated from human IL-2 activated killer cells. |journal=J. Immunol. |volume=141 |issue= 9 |pages= 3142–7 |year= 1988 |pmid= 3262682 |doi=
*cite journal | author=Przetak MM, Yoast S, Schmidt BF |title=Cloning of cDNA for human granzyme 3. |journal=FEBS Lett. |volume=364 |issue= 3 |pages= 268–71 |year= 1995 |pmid= 7758581 |doi=
*cite journal | author=Baker E, Sayers TJ, Sutherland GR, Smyth MJ |title=The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases. |journal=Immunogenetics |volume=40 |issue= 3 |pages= 235–7 |year= 1994 |pmid= 8039831 |doi=
*cite journal | author=Sayers TJ, Lloyd AR, McVicar DW, "et al." |title=Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. |journal=J. Leukoc. Biol. |volume=59 |issue= 5 |pages= 763–8 |year= 1996 |pmid= 8656064 |doi=
*cite journal | author=Hink-Schauer C, Estébanez-Perpiñá E, Wilharm E, "et al." |title=The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50923–33 |year= 2003 |pmid= 12384499 |doi= 10.1074/jbc.M207962200
*cite journal | author=Fajardo I, Pejler G |title=Formation of active monomers from tetrameric human beta-tryptase. |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 603–10 |year= 2003 |pmid= 12387726 |doi= 10.1042/BJ20021418
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Zhao T, Zhang H, Guo Y, "et al." |title=Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. |journal=Cell Death Differ. |volume=14 |issue= 3 |pages= 489–99 |year= 2007 |pmid= 17008916 |doi= 10.1038/sj.cdd.4402040
*cite journal | author=Zhao T, Zhang H, Guo Y, Fan Z |title=Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 12104–11 |year= 2007 |pmid= 17308307 |doi= 10.1074/jbc.M611006200
*cite journal | author=Rucevic M, Fast LD, Jay GD, "et al." |title=Altered levels and molecular forms of granzyme k in plasma from septic patients. |journal=Shock |volume=27 |issue= 5 |pages= 488–93 |year= 2007 |pmid= 17438453 |doi= 10.1097/01.shk.0000246905.24895.e5

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