- KLK1
Kallikrein 1, also known as KLK1, is a human
gene .PBB_Summary
section_title =
summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.cite web | title = Entrez Gene: KLK1 kallikrein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3816| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Clements J, Hooper J, Dong Y, Harvey T |title=The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions. |journal=Biol. Chem. |volume=382 |issue= 1 |pages= 5–14 |year= 2001 |pmid= 11258672 |doi=
*cite journal | author=Lottspeich F, Geiger R, Henschen A, Kutzbach C |title=N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases. |journal=Hoppe-Seyler's Z. Physiol. Chem. |volume=360 |issue= 12 |pages= 1947–50 |year= 1980 |pmid= 393608 |doi=
*cite journal | author=Riegman PH, Vlietstra RJ, Suurmeijer L, "et al." |title=Characterization of the human kallikrein locus. |journal=Genomics |volume=14 |issue= 1 |pages= 6–11 |year= 1992 |pmid= 1385301 |doi=
*cite journal | author=Richards RI, Holman K, Shen Y, "et al." |title=Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker. |journal=Genomics |volume=11 |issue= 1 |pages= 77–82 |year= 1992 |pmid= 1684954 |doi=
*cite journal | author=Henttu P, Lukkarinen O, Vihko P |title=Expression of the gene coding for human prostate-specific antigen and related hGK-1 in benign and malignant tumors of the human prostate. |journal=Int. J. Cancer |volume=45 |issue= 4 |pages= 654–60 |year= 1990 |pmid= 1691151 |doi=
*cite journal | author=Qin H, Kemp J, Yip MY, "et al." |title=Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization. |journal=Hum. Hered. |volume=41 |issue= 4 |pages= 222–6 |year= 1992 |pmid= 1783409 |doi=
*cite journal | author=Lu HS, Lin FK, Chao L, Chao J |title=Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation. |journal=Int. J. Pept. Protein Res. |volume=33 |issue= 4 |pages= 237–49 |year= 1989 |pmid= 2666327 |doi=
*cite journal | author=Angermann A, Bergmann C, Appelhans H |title=Cloning and expression of human salivary-gland kallikrein in Escherichia coli. |journal=Biochem. J. |volume=262 |issue= 3 |pages= 787–93 |year= 1990 |pmid= 2686621 |doi=
*cite journal | author=Evans BA, Yun ZX, Close JA, "et al." |title=Structure and chromosomal localization of the human renal kallikrein gene. |journal=Biochemistry |volume=27 |issue= 9 |pages= 3124–9 |year= 1988 |pmid= 2898948 |doi=
*cite journal | author=Fukushima D, Kitamura N, Nakanishi S |title=Nucleotide sequence of cloned cDNA for human pancreatic kallikrein. |journal=Biochemistry |volume=24 |issue= 27 |pages= 8037–43 |year= 1986 |pmid= 3004571 |doi=
*cite journal | author=Kellermann J, Lottspeich F, Geiger R, Deutzmann R |title=Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites. |journal=Protein Seq. Data Anal. |volume=1 |issue= 3 |pages= 177–82 |year= 1988 |pmid= 3163150 |doi=
*cite journal | author=Takahashi S, Irie A, Katayama Y, "et al." |title=N-terminal amino acid sequence of human urinary prokallikrein. |journal=J. Biochem. |volume=99 |issue= 3 |pages= 989–92 |year= 1986 |pmid= 3635530 |doi=
*cite journal | author=Baker AR, Shine J |title=Human kidney kallikrein: cDNA cloning and sequence analysis. |journal=DNA |volume=4 |issue= 6 |pages= 445–50 |year= 1986 |pmid= 3853975 |doi=
*cite journal | author=Del Nery E, Chagas JR, Juliano MA, "et al." |title=Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments. |journal=Biochem. J. |volume=312 ( Pt 1) |issue= |pages= 233–8 |year= 1996 |pmid= 7492318 |doi=
*cite journal | author=Chen LM, Richards GP, Chao L, Chao J |title=Molecular cloning, purification and in situ localization of human colon kallikrein. |journal=Biochem. J. |volume=307 ( Pt 2) |issue= |pages= 481–6 |year= 1995 |pmid= 7733886 |doi=
*cite journal | author=Clements J, Mukhtar A, Ehrlich A, Yap B |title=Glandular kallikrein gene expression in the human uterus. |journal=Braz. J. Med. Biol. Res. |volume=27 |issue= 8 |pages= 1855–63 |year= 1995 |pmid= 7749374 |doi=
*cite journal | author=Lin FK, Lin CH, Chou CC, "et al." |title=Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes. |journal=Biochim. Biophys. Acta |volume=1173 |issue= 3 |pages= 325–8 |year= 1993 |pmid= 7916636 |doi=
*cite journal | author=Gomes RA, Juliano L, Chagas JR, Hial V |title=Characterization of kininogenase activity of an acidic proteinase isolated from human kidney. |journal=Can. J. Physiol. Pharmacol. |volume=75 |issue= 6 |pages= 757–61 |year= 1997 |pmid= 9276160 |doi=
*cite journal | author=Bourgeois L, Brillard-Bourdet M, Deperthes D, "et al." |title=Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29590–5 |year= 1997 |pmid= 9368023 |doi=
*cite journal | author=Chen VC, Chao L, Chao J |title=Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis. |journal=Biochim. Biophys. Acta |volume=1479 |issue= 1-2 |pages= 237–46 |year= 2000 |pmid= 10862973 |doi=PBB_Controls
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