[cite web | title = Entrez Gene: TMPO thymopoietin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7112| accessdate = ] ]Thymopoietin is a protein involved in the induction of CD90 in the thymus. The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. The human TMPO gene maps to chromosome band 12q22 and consists of eight exons. TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the nuclear membrane. TMPO beta is a human homolog of the murine protein LAP2 (lamina-associated polypeptide 2). LAP2 plays a role in the regulation of nuclear architecture by binding lamin B1 and chromosomes. This interaction is regulated by phosphorylation during mitosis. Given the nuclear localization of the three TMPO isoforms, it is unlikely that these proteins play any role in CD90 induction.
References
Further reading
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citations =
*cite journal | author=Dechat T, Vlcek S, Foisner R |title=Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics. |journal=J. Struct. Biol. |volume=129 |issue= 2-3 |pages= 335–45 |year= 2000 |pmid= 10806084 |doi= 10.1006/jsbi.2000.4212
*cite journal | author=Twomey JJ, Goldstein G, Lewis VM, "et al." |title=Bioassay determinations of thymopoietin and thymic hormone levels in human plasma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=74 |issue= 6 |pages= 2541–5 |year= 1977 |pmid= 302007 |doi=
*cite journal | author=Heavner GA, Audhya T, Goldstein G |title=Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines. |journal=Regul. Pept. |volume=27 |issue= 2 |pages= 257–62 |year= 1990 |pmid= 2158125 |doi=
*cite journal | author=Audhya T, Schlesinger DH, Goldstein G |title=Isolation and complete amino acid sequence of human thymopoietin and splenin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 11 |pages= 3545–9 |year= 1987 |pmid= 3473468 |doi=
*cite journal | author=Fuccello A, Audhya T, Talle MA, Goldstein G |title=Immunoassay for bovine serum thymopoietin: discrimination from splenin by monoclonal antibodies. |journal=Arch. Biochem. Biophys. |volume=228 |issue= 1 |pages= 292–8 |year= 1984 |pmid= 6364989 |doi=
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*cite journal | author=Dechat T, Gotzmann J, Stockinger A, "et al." |title=Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics. |journal=EMBO J. |volume=17 |issue= 16 |pages= 4887–902 |year= 1998 |pmid= 9707448 |doi= 10.1093/emboj/17.16.4887
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