Lipotropin

Lipotropin

protein
Name = proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
caption =


width =
HGNCid = 9201
Symbol = POMC
AltSymbols =
EntrezGene = 5443
OMIM = 176830
RefSeq = NM_000939
UniProt = P01189
PDB =
ECnumber =
Chromosome = 2
Arm = p
Band = 23
LocusSupplementaryData =

Lipotropin is a hormone produced by the cleavage of pro-opiomelanocortin (POMC). The anterior pituitary gland produces the pro-hormone POMC, which undergoes cleavage to adrenocorticotropin (ACTH) and β-lipotropin (β-LPH).

Beta-lipotropin

β-lipotropin is a 90 amino acid polypeptide that is the carboxy-terminal fragment of POMC.

It stimulates melanocytes to produce melanin, and can also be cleaved into smaller peptides. In humans, γ-lipotropin, α-MSH, β-MSH, γ-MSH, α-endorphin, β-endorphin, γ-endorphin, and met-enkephalin are all possible fragments of β-lipotropin. [citation | url=http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=346829&blobtype=pdf | title= NH2-Terminal amino acid sequence and peptide mapping of purified human β-lipotropin: Comparison with previously proposed sequences |author= Joachim Spiess, Charles D. Mount, Wendell E. Nicholson, David N. Orth | journal= Proc. Natl. Acad. Sci. USA | page= 5071-5 |volume= 79 |year= 1982 |accessdate= 2007-06-21]

β-lipotropin also performs lipid-mobilizing functions such as lipolysis and steroidogenesis.

Gamma-lipotropin

γ-lipotropin is the amino-terminal peptide fragment of β-lipotropin. In humans, it has 56 amino acids.

External links

*
*

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • lipotropin — [lip΄ōtrō′pin] n. a hormone made in the pituitary gland, that stimulates release of fatty acids from adipose tissue: its amino acid sequence includes an endorphin …   English World dictionary

  • Lipotropin — Proopiomelanocortin Derivate POMC       γ MSH ACTH …   Deutsch Wikipedia

  • lipotropin — A pituitary hormone mobilizing fat from adipose tissue. β L. is a single chain peptide of 91 amino acyl residues that contains the sequences of endorphins, metenkephalin, and β melanotropin; γ l. is shorter and is identical in sequence to the N… …   Medical dictionary

  • Lipotropin — Li|po|tro|pin [↑ Lip u. ↑ tropin], das; s, e; Syn.: lipotropes Hormon (LPH): den Fettstoffwechsel steuernde Hypophysen Hormone aus 89–93 Aminosäuren (β L.) sowie 58 Aminosäuren (γ L.), deren Sequenzen teilw. mit denen von Corticotropin,… …   Universal-Lexikon

  • lipotropin — lipotropinas statusas T sritis chemija apibrėžtis Baltyminis hipofizės hormonas. atitikmenys: angl. lipotropic hormone; lipotropin rus. липотропин; липотропный гормон ryšiai: sinonimas – lipotropinis hormonas …   Chemijos terminų aiškinamasis žodynas

  • lipotropin — ˌlipəˈtrōpə̇n, ˌlī noun ( s) Etymology: lipotropic + in : either of two protein hormones of the adenohypophysis that function in the mobilization of fat reserves ; especially : beta lipotropin herein …   Useful english dictionary

  • lipotropin — noun Date: 1964 either of two protein hormones of the pituitary gland that function in the mobilization of fat reserves …   New Collegiate Dictionary

  • lipotropin — (= LPH; lipotropic hormone; adipokinetic hormone) Polypeptide hormone ( b form: 9894D, 91 residues; g form has only residues 1 58 of b ) from the pituitary hypophysis, that is of particular interest because it is the precursor of endorphins,… …   Dictionary of molecular biology

  • lipotropin — /lip euh troh pin, luy peuh /, n. Biochem. a large polypeptide of the pituitary gland from which endorphins and other endogenous opiates are thought to derive. [1960 65; LIPOTROP(IC) + IN2] * * * …   Universalium

  • lipotropin — noun A pituitary hormone that promotes the metabolism of fat, and is a precursor to the endorphins …   Wiktionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”