Arotinolol

Drugbox
IUPAC_name = 5-(2-{ [3-("tert"-butylamino)-2-hydroxypropyl] sulfanyl}- 1,3-thiazol-4-yl)thiophene-2-carboxamide

---

CAS_number = 41287-43-8
CAS_supplemental =
ATC_prefix =
ATC_suffix =
ATC_supplemental =
PubChem = 2239
DrugBank =
chemical_formula =
C=15 | H=21 | N=3 | O=2 | S=3
molecular_weight = 371.54 g/mol
smiles = CC(C)(C)NCC(CSC1=NC(=CS1)C2=CC=C(S2)C(=O)N)O
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status = Rx-only
routes_of_administration = Oral

Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. cite journal |author=Zhao J, Golozoubova V, Cannon B, Nedergaard J |title=Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes |journal=Can. J. Physiol. Pharmacol. |volume=79 |issue=7 |pages=585–93 |year=2001 |month=July |pmid=11478592 |doi= |url=http://article.pubs.nrc-cnrc.gc.ca/ppv/RPViewDoc?issn=0008-4212&volume=79&issue=7&startPage=585]

Uses

It is used in the treatment of high blood pressure.cite journal |author=Wu H, Zhang Y, Huang J, "et al" |title=Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers |journal=Hypertens. Res. |volume=24 |issue=5 |pages=605–10 |year=2001 |month=September |pmid=11675958 |doi= |url=http://joi.jlc.jst.go.jp/JST.JSTAGE/hypres/24.605?from=PubMed]

It has been proposed for use in treatment of essential tremor.cite journal |author=Lee KS, Kim JS, Kim JW, Lee WY, Jeon BS, Kim D |title=A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor |journal=Parkinsonism Relat. Disord. |volume=9 |issue=6 |pages=341–7 |year=2003 |month=August |pmid=12853233 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S1353802003000294]

References

External links

* [http://ds-pharma.jp/medical/product/dbps_data/_material_/product/almarl/almarl_tab_tenpu.pdf Almarl アルマール] (PDF) Dainippon Sumitomo Pharma. April 2002.
* [http://www.ds-pharma.co.jp Official Dainippon Sumitomo Pharma Website]