Pancreatic polypeptide

Pancreatic polypeptide

protein
Name = pancreatic polypeptide
caption = IHC for Pancreatic Polypeptide in a mouse pancreas, 200x.



width =
HGNCid = 9327
Symbol = PPY
AltSymbols =
EntrezGene = 5539
OMIM = 167780
RefSeq = NM_002722
UniProt = P01298
PDB =
ECnumber =
Chromosome = 17
Arm = p
Band = 11.1
LocusSupplementaryData = -qter

Pancreatic polypeptide is a polypeptide secreted by PP cells in the endocrine pancreas predominantly in the head of the pancreas. It consists of 36 amino acids and has molecular weight about 4200 Da.

The function of PP is to self regulate the pancreas secretion activities (endocrine and exocrine), it also effects on hepatic glycogen levels and gastrointestinal secretions.

Its secretion in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose.

External links

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* BBC [http://news.bbc.co.uk/1/hi/health/6262347.stm Hope over 'obesity-busting gum'] 15 January 2007


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