Gastric inhibitory polypeptide receptor

Gastric inhibitory polypeptide receptor

Gastric inhibitory polypeptide receptors (GIPRs) are seven-transmembrane proteins found on beta-cells in the pancreas.cite web|title=Gastrointestinal Hormones and Peptides | url = http://web.indstate.edu/thcme/mwking/peptide-hormones.html#gastrin | accessdate = 2007-08-24] cite journal | author = Brubaker PL, Drucker DJ | title = Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors | journal = Recept. Channels | volume = 8 | issue = 3-4 | pages = 179–88 | year = 2002 | pmid = 12529935 | doi = | issn = | url = http://www.glucagon.com/Receptors%20and%20Channels.pdf | accessdate = 2007-08-24 | format = dead link|date=June 2008 – [http://scholar.google.co.uk/scholar?hl=en&lr=&q=author%3A+intitle%3AStructure-function+of+the+glucagon+receptor+family+of+G+protein-coupled+receptors%3A+the+glucagon%2C+GIP%2C+GLP-1%2C+and+GLP-2+receptors&as_publication=Recept.+Channels&as_ylo=2002&as_yhi=2002&btnG=Search Scholar search] ]

They bind gastric inhibitory polypeptide.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yamada Y, Seino Y |title=Physiology of GIP--a lesson from GIP receptor knockout mice. |journal=Horm. Metab. Res. |volume=36 |issue= 11-12 |pages= 771–4 |year= 2005 |pmid= 15655707 |doi= 10.1055/s-2004-826162
*cite journal | author=Stoffel M, Fernald AA, Le Beau MM, Bell GI |title=Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization. |journal=Genomics |volume=28 |issue= 3 |pages= 607–9 |year= 1996 |pmid= 7490109 |doi= 10.1006/geno.1995.1203
*cite journal | author=Gremlich S, Porret A, Hani EH, "et al." |title=Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor. |journal=Diabetes |volume=44 |issue= 10 |pages= 1202–8 |year= 1995 |pmid= 7556958 |doi=
*cite journal | author=Volz A, Göke R, Lankat-Buttgereit B, "et al." |title=Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma. |journal=FEBS Lett. |volume=373 |issue= 1 |pages= 23–9 |year= 1995 |pmid= 7589426 |doi=
*cite journal | author=Usdin TB, Mezey E, Button DC, "et al." |title=Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. |journal=Endocrinology |volume=133 |issue= 6 |pages= 2861–70 |year= 1994 |pmid= 8243312 |doi=
*cite journal | author=Yamada Y, Hayami T, Nakamura K, "et al." |title=Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA. |journal=Genomics |volume=29 |issue= 3 |pages= 773–6 |year= 1996 |pmid= 8575774 |doi= 10.1006/geno.1995.9937
*cite journal | author=Gallwitz B, Witt M, Morys-Wortmann C, "et al." |title=GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1. |journal=Regul. Pept. |volume=63 |issue= 1 |pages= 17–22 |year= 1997 |pmid= 8795084 |doi=
*cite journal | author=N'Diaye N, Tremblay J, Hamet P, "et al." |title=Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 8 |pages= 2781–5 |year= 1998 |pmid= 9709947 |doi=
*cite journal | author=Tseng CC, Zhang XY |title=Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling. |journal=Endocrinology |volume=141 |issue= 3 |pages= 947–52 |year= 2000 |pmid= 10698169 |doi=
*cite journal | author=Bollag RJ, Zhong Q, Phillips P, "et al." |title=Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors. |journal=Endocrinology |volume=141 |issue= 3 |pages= 1228–35 |year= 2000 |pmid= 10698200 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Baldacchino V, Oble S, Hamet P, "et al." |title=Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene. |journal=Endocr. Res. |volume=28 |issue= 4 |pages= 577 |year= 2003 |pmid= 12530665 |doi=
*cite journal | author=Antonini SR, N'Diaye N, Hamet P, "et al." |title=Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS). |journal=Endocr. Res. |volume=28 |issue= 4 |pages= 755–6 |year= 2003 |pmid= 12530694 |doi=
*cite journal | author=Manhart S, Hinke SA, McIntosh CH, "et al." |title=Structure-function analysis of a series of novel GIP analogues containing different helical length linkers. |journal=Biochemistry |volume=42 |issue= 10 |pages= 3081–8 |year= 2003 |pmid= 12627975 |doi= 10.1021/bi026868e
*cite journal | author=Ding KH, Zhong Q, Isales CM |title=Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=285 |issue= 2 |pages= E390–6 |year= 2003 |pmid= 12721154 |doi= 10.1152/ajpendo.00509.2002
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Hansotia T, Baggio LL, Delmeire D, "et al." |title=Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors. |journal=Diabetes |volume=53 |issue= 5 |pages= 1326–35 |year= 2004 |pmid= 15111503 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Baldacchino V, Oble S, Hamet P, "et al." |title=The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter. |journal=Endocr. Res. |volume=30 |issue= 4 |pages= 805–6 |year= 2005 |pmid= 15666829 |doi=

External links

* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2294 IUPHAR GPCR Database - GIP receptor]
*

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